Detailed information of TA system TA024655

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE-YafN
• Location: 1784444..1784969
• Replicon: chromosome
• Accession: NC_013959
• Organism: Sideroxydans lithotrophicus ES-1

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: D5CSR6
• Locus tag: SLIT_RS08850
• Protein ID: WP_013029900.1
• Coordinates: 1784444..1784725 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D5CSR7
• Locus tag: SLIT_RS08855
• Protein ID: WP_013029901.1
• Coordinates: 1784715..1784969 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SLIT_RS08825	1781356..1781679	+	324	WP_013029895.1	type II toxin-antitoxin system RelE/ParE family toxin	-
SLIT_RS08830	1781676..1782002	+	327	WP_013029896.1	putative addiction module antidote protein	-
SLIT_RS08835	1782193..1782924	+	732	WP_150102983.1	hypothetical protein	-
SLIT_RS08840	1783050..1783610	+	561	WP_013029898.1	peroxiredoxin	-
SLIT_RS08845	1783800..1784084	-	285	WP_150103075.1	c-type cytochrome	-
SLIT_RS08850	1784444..1784725	-	282	WP_013029900.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SLIT_RS08855	1784715..1784969	-	255	WP_013029901.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SLIT_RS08860	1785041..1785928	-	888	WP_013029902.1	ROK family protein	-
SLIT_RS08865	1786047..1786994	+	948	WP_049870978.1	sensor domain-containing diguanylate cyclase	-
SLIT_RS08870	1787016..1787459	-	444	WP_013029904.1	D-tyrosyl-tRNA(Tyr) deacylase	-
SLIT_RS15235	1787493..1788770	-	1278	WP_013029905.1	hypothetical protein	-
SLIT_RS08880	1788991..1789281	+	291	WP_013029906.1	DUF427 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-75)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10883.81 Da
• Isoelectric Point: 10.8690

>T24655 WP_013029900.1 NC_013959:c1784725-1784444 [Sideroxydans lithotrophicus ES-1]
MSYELSFHPDALAEWKKLDGSIRELFKKKLAERLHNPRIPAARLSGQKDRYKIKQRDAGYRLVYEVRDKVLVIVVVAVGK
RERNMVYKAAAKR

Nucleotide

• Length: 282 bp

>T24655 NC_013959:c1784725-1784444 [Sideroxydans lithotrophicus ES-1]
ATGAGTTATGAACTGAGCTTCCACCCCGATGCATTGGCGGAATGGAAAAAGCTCGATGGTTCGATACGCGAACTGTTCAA
GAAGAAACTTGCAGAACGACTGCACAATCCCCGCATCCCCGCCGCCCGCCTTTCCGGGCAGAAAGACCGCTACAAGATCA
AGCAGCGCGACGCAGGCTACCGGCTTGTGTACGAAGTCCGCGACAAAGTGCTGGTGATCGTGGTCGTCGCCGTGGGCAAG
CGTGAGCGCAACATGGTGTACAAGGCTGCGGCGAAGCGGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9059.53 Da
• Isoelectric Point: 5.8124

>AT24655 WP_013029901.1 NC_013959:c1784969-1784715 [Sideroxydans lithotrophicus ES-1]
MAHAILASTTASISELKKNPMATVAAGDGFPVAILNRNEPTFYCVPAKAYEALMDKLEDAELNALADARLKDGKRLVKVK
LDEL

Nucleotide

• Length: 255 bp

>AT24655 NC_013959:c1784969-1784715 [Sideroxydans lithotrophicus ES-1]
ATGGCACATGCAATTCTGGCATCCACCACGGCCAGCATCTCCGAACTGAAAAAGAACCCGATGGCGACAGTCGCCGCTGG
CGACGGTTTCCCTGTCGCCATCCTTAACCGCAACGAACCTACCTTCTACTGCGTTCCGGCCAAGGCCTACGAAGCGCTGA
TGGATAAGCTGGAAGATGCCGAACTCAATGCACTGGCCGATGCTCGCCTGAAAGATGGAAAACGTCTGGTCAAGGTGAAG
CTGGATGAGTTATGA

Structures

Toxin

• AlphaFold DB: D5CSR6

Antitoxin

• AlphaFold DB: D5CSR7