246546

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 1912401..1913095 Replicon chromosome
Accession NZ_CP098025
Organism Enterococcus faecalis strain QZ076

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag NAG05_RS09720 Protein ID WP_002395798.1
Coordinates 1912751..1913095 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag NAG05_RS09715 Protein ID WP_002364355.1
Coordinates 1912401..1912733 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG05_RS09665 (1907668) 1907668..1907886 - 219 WP_016626784.1 hypothetical protein -
NAG05_RS09670 (1907888) 1907888..1908799 - 912 WP_250652839.1 YqaJ viral recombinase family protein -
NAG05_RS09675 (1908801) 1908801..1909061 - 261 WP_231450472.1 hypothetical protein -
NAG05_RS09680 (1909065) 1909065..1910261 - 1197 WP_250652956.1 DEAD/DEAH box helicase -
NAG05_RS09685 (1910251) 1910251..1910544 - 294 WP_002407629.1 recombinase RecB -
NAG05_RS09690 (1910541) 1910541..1910741 - 201 WP_202577733.1 hypothetical protein -
NAG05_RS09700 (1910953) 1910953..1911348 - 396 WP_231450469.1 hypothetical protein -
NAG05_RS09705 (1911591) 1911591..1911902 - 312 WP_250652840.1 hypothetical protein -
NAG05_RS09710 (1911913) 1911913..1912089 - 177 WP_002364354.1 helix-turn-helix transcriptional regulator -
NAG05_RS09715 (1912401) 1912401..1912733 + 333 WP_002364355.1 helix-turn-helix transcriptional regulator Antitoxin
NAG05_RS09720 (1912751) 1912751..1913095 + 345 WP_002395798.1 ImmA/IrrE family metallo-endopeptidase Toxin
NAG05_RS09725 (1913129) 1913129..1913857 + 729 WP_126262607.1 potassium channel family protein -
NAG05_RS09730 (1913954) 1913954..1915102 + 1149 WP_126262606.1 site-specific integrase -
NAG05_RS09735 (1915130) 1915130..1915573 - 444 WP_125203765.1 competence type IV pilus minor pilin ComGD -
NAG05_RS09740 (1915570) 1915570..1915845 - 276 WP_002356991.1 competence type IV pilus major pilin ComGC -
NAG05_RS09745 (1915845) 1915845..1916891 - 1047 WP_002356990.1 competence type IV pilus assembly protein ComGB -
NAG05_RS09750 (1916848) 1916848..1917816 - 969 WP_002374519.1 competence type IV pilus ATPase ComGA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1869799..1915546 45747


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(22-81)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13718.69 Da        Isoelectric Point: 6.1363

>T246546 WP_002395798.1 NZ_CP098025:1912751-1913095 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYMELYKIPSFRNKMEAEADH
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLK

Download         Length: 345 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12691.16 Da        Isoelectric Point: 4.6307

>AT246546 WP_002364355.1 NZ_CP098025:1912401-1912733 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References