Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 681075..681631 Replicon chromosome
Accession NC_013959
Organism Sideroxydans lithotrophicus ES-1

Toxin (Protein)


Gene name vapC Uniprot ID D5CNK3
Locus tag SLIT_RS03365 Protein ID WP_013028815.1
Coordinates 681075..681404 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5CNK4
Locus tag SLIT_RS03370 Protein ID WP_013028816.1
Coordinates 681407..681631 (-) Length 75 a.a.

Genomic Context

SLIT_RS03350SLIT_RS03355SLIT_RS03360SLIT_RS03345SLIT_RS03365SLIT_RS03370SLIT_RS03375SLIT_RS03380SLIT_RS03385SLIT_RS03390
Location: 677487..679166 (1680 bp)
Type: Others
Protein ID: WP_013028812.1
Location: 679163..679513 (351 bp)
Type: Others
Protein ID: WP_013028813.1
Location: 679521..680996 (1476 bp)
Type: Others
Protein ID: WP_013028814.1
Location: 676299..677336 (1038 bp)
Type: Others
Protein ID: WP_013028811.1
Location: 681075..681404 (330 bp)
Type: Toxin
Protein ID: WP_013028815.1
Location: 681407..681631 (225 bp)
Type: Antitoxin
Protein ID: WP_013028816.1
Location: 681830..682507 (678 bp)
Type: Others
Protein ID: WP_013028817.1
Location: 682504..684291 (1788 bp)
Type: Others
Protein ID: WP_013028818.1
Location: 684306..684674 (369 bp)
Type: Others
Protein ID: WP_013028819.1
Location: 684671..685267 (597 bp)
Type: Others
Protein ID: WP_013028820.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SLIT_RS03345676299..677336-1038WP_013028811.1tetratricopeptide repeat protein-
SLIT_RS03350677487..679166+1680WP_013028812.1glutamine--tRNA ligase/YqeY domain fusion protein-
SLIT_RS03355679163..679513+351WP_013028813.1membrane protein-
SLIT_RS03360679521..680996+1476WP_013028814.1cysteine--tRNA ligase-
SLIT_RS03365681075..681404-330WP_013028815.1DUF5615 family PIN-like proteinToxin
SLIT_RS03370681407..681631-225WP_013028816.1DUF433 domain-containing proteinAntitoxin
SLIT_RS03375681830..682507-678WP_013028817.1prepilin-type N-terminal cleavage/methylation domain-containing protein-
SLIT_RS03380682504..684291-1788WP_013028818.1hypothetical protein-
SLIT_RS03385684306..684674-369WP_013028819.1hypothetical protein-
SLIT_RS03390684671..685267-597WP_013028820.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--671609..68163110022


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(1-77)

Antitoxin

Protein of unknown function DUF433

(7-62)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11965.78 Da        Isoelectric Point: 4.7584

>T24653 WP_013028815.1 NC_013959:c681404-681075 [Sideroxydans lithotrophicus ES-1]
MRFLVDAQLPPALARYLSSAGHQAEHVYDIGLAAASDRIIWNYAVSNHAAIFTKDEDFVSMVGTSADAPPIVWVRVGNIG
KQALLTWIEPMMARIISEIEAGEKLIEIT

Download         Length: 330 bp

>T24653 NC_013959:c681404-681075 [Sideroxydans lithotrophicus ES-1]
ATGAGATTTCTTGTCGATGCGCAGCTTCCGCCCGCGCTGGCGCGCTACCTCAGTAGCGCAGGACATCAGGCAGAGCACGT
CTATGACATAGGATTGGCGGCAGCAAGCGACAGGATCATCTGGAACTACGCCGTCTCAAATCACGCTGCCATCTTCACCA
AAGACGAGGACTTCGTCAGCATGGTCGGCACCAGTGCGGACGCGCCGCCGATAGTTTGGGTACGCGTTGGAAATATTGGC
AAACAGGCCTTGCTGACCTGGATAGAACCGATGATGGCGCGAATCATCTCCGAGATCGAAGCAGGAGAAAAGCTGATTGA
GATTACCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8279.65 Da        Isoelectric Point: 4.6854

>AT24653 WP_013028816.1 NC_013959:c681631-681407 [Sideroxydans lithotrophicus ES-1]
MGQVTRITVDPNMCGGRPCIRGLRVRVKDVLEMLASGMTREEILKDFPYLETEDITATLEYAAMQVDHPILQAA

Download         Length: 225 bp

>AT24653 NC_013959:c681631-681407 [Sideroxydans lithotrophicus ES-1]
ATGGGACAAGTCACCAGAATCACCGTTGACCCGAATATGTGCGGTGGCAGGCCTTGTATTCGCGGTCTACGGGTACGTGT
AAAAGACGTACTGGAAATGCTGGCATCCGGCATGACCAGAGAAGAAATTCTCAAAGATTTCCCTTATCTTGAAACCGAGG
ATATTACTGCCACACTTGAATATGCTGCCATGCAAGTAGACCACCCAATACTGCAAGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBD5CNK3

Antitoxin

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Source
ID
Structure
AlphaFold DBD5CNK4

References