Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 914606..915132 Replicon chromosome
Accession NZ_CP097887
Organism Staphylococcus arlettae strain SA283

Toxin (Protein)


Gene name mazF Uniprot ID A0A7V7SNP8
Locus tag NAA64_RS04340 Protein ID WP_002509017.1
Coordinates 914776..915132 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7V7VEP5
Locus tag NAA64_RS04335 Protein ID WP_002509016.1
Coordinates 914606..914776 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAA64_RS04310 (NAA64_04310) 910433..910906 + 474 WP_002509011.1 hypothetical protein -
NAA64_RS04315 (NAA64_04315) 910899..912395 + 1497 WP_167868166.1 PH domain-containing protein -
NAA64_RS04320 (NAA64_04320) 912388..912861 + 474 WP_021459211.1 PH domain-containing protein -
NAA64_RS04325 (NAA64_04325) 912904..913257 + 354 WP_002509014.1 holo-ACP synthase -
NAA64_RS04330 (NAA64_04330) 913369..914517 + 1149 WP_002509015.1 alanine racemase -
NAA64_RS04335 (NAA64_04335) 914606..914776 + 171 WP_002509016.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NAA64_RS04340 (NAA64_04340) 914776..915132 + 357 WP_002509017.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NAA64_RS04345 (NAA64_04345) 915404..916405 + 1002 WP_103387740.1 PP2C family protein-serine/threonine phosphatase -
NAA64_RS04350 (NAA64_04350) 916488..916814 + 327 WP_002509019.1 anti-sigma factor antagonist -
NAA64_RS04355 (NAA64_04355) 916816..917295 + 480 WP_002509020.1 anti-sigma B factor RsbW -
NAA64_RS04360 (NAA64_04360) 917270..918040 + 771 WP_103387739.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13385.57 Da        Isoelectric Point: 10.2885

>T246510 WP_002509017.1 NZ_CP097887:914776-915132 [Staphylococcus arlettae]
MRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIRT
LDKKRLKEKLTYLSEDKMKEVNIAIDISLGLHNNRHHK

Download         Length: 357 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6236.72 Da        Isoelectric Point: 3.8099

>AT246510 WP_002509016.1 NZ_CP097887:914606-914776 [Staphylococcus arlettae]
MPSFNQSRNHNIEQSLKEGYSQMADLNLSLAAEAFPFECEACDCNESYISASNTND

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V7SNP8

Antitoxin

Source ID Structure
AlphaFold DB A0A7V7VEP5

References