Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 903489..904000 Replicon chromosome
Accession NZ_CP097887
Organism Staphylococcus arlettae strain SA283

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7V7VCW3
Locus tag NAA64_RS04280 Protein ID WP_002509005.1
Coordinates 903794..904000 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A7V7SPC1
Locus tag NAA64_RS04275 Protein ID WP_002509004.1
Coordinates 903489..903782 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAA64_RS04250 (NAA64_04250) 898700..899482 + 783 WP_103387750.1 hydroxyethylthiazole kinase -
NAA64_RS04255 (NAA64_04255) 899486..900121 + 636 WP_103387746.1 thiamine phosphate synthase -
NAA64_RS04260 (NAA64_04260) 900208..901074 + 867 WP_167868163.1 membrane protein insertase YidC -
NAA64_RS04265 (NAA64_04265) 901133..901774 - 642 WP_167868168.1 HD domain-containing protein -
NAA64_RS04270 (NAA64_04270) 901865..903349 - 1485 WP_103387744.1 cardiolipin synthase -
NAA64_RS04275 (NAA64_04275) 903489..903782 + 294 WP_002509004.1 copper-sensing transcriptional repressor CsoR Antitoxin
NAA64_RS04280 (NAA64_04280) 903794..904000 + 207 WP_002509005.1 hypothetical protein Toxin
NAA64_RS04285 (NAA64_04285) 904170..904310 + 141 WP_002509006.1 Lmo0850 family protein -
NAA64_RS04290 (NAA64_04290) 904358..905554 - 1197 WP_103387743.1 FtsW/RodA/SpoVE family cell cycle protein -
NAA64_RS04295 (NAA64_04295) 905794..906864 + 1071 WP_167868164.1 D-alanine--D-alanine ligase -
NAA64_RS04300 (NAA64_04300) 906876..908231 + 1356 WP_002509009.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(24-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7723.91 Da        Isoelectric Point: 5.5509

>T246509 WP_002509005.1 NZ_CP097887:903794-904000 [Staphylococcus arlettae]
MESKVIFLAGLTSYKQQAQLTQKLLNIIGVHQVHVSLEKSIVQITFDTPANLNNIEKEIYDDGYTILF

Download         Length: 207 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11043.67 Da        Isoelectric Point: 6.8617

>AT246509 WP_002509004.1 NZ_CP097887:903489-903782 [Staphylococcus arlettae]
MTEVDKAHHSTQTKANLKSRLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNAGEQ
EAAMEELLVTFQKLMKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V7VCW3

Antitoxin

Source ID Structure
AlphaFold DB A0A7V7SPC1

References