Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4061526..4062144 Replicon chromosome
Accession NZ_CP097884
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NAG72_RS19770 Protein ID WP_001291435.1
Coordinates 4061926..4062144 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NAG72_RS19765 Protein ID WP_000344800.1
Coordinates 4061526..4061900 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG72_RS19755 (4056615) 4056615..4057808 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NAG72_RS19760 (4057831) 4057831..4060980 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NAG72_RS19765 (4061526) 4061526..4061900 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NAG72_RS19770 (4061926) 4061926..4062144 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NAG72_RS19775 (4062316) 4062316..4062867 + 552 WP_000102564.1 maltose O-acetyltransferase -
NAG72_RS19780 (4062983) 4062983..4063453 + 471 WP_000136192.1 YlaC family protein -
NAG72_RS19785 (4063617) 4063617..4065167 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NAG72_RS19790 (4065209) 4065209..4065562 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NAG72_RS19800 (4065941) 4065941..4066252 + 312 WP_000409911.1 MGMT family protein -
NAG72_RS19805 (4066283) 4066283..4066855 - 573 WP_000779842.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T246503 WP_001291435.1 NZ_CP097884:4061926-4062144 [Escherichia coli str. K-12 substr. MG1655]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT246503 WP_000344800.1 NZ_CP097884:4061526-4061900 [Escherichia coli str. K-12 substr. MG1655]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References