Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2983489..2984127 Replicon chromosome
Accession NZ_CP097884
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NAG72_RS14355 Protein ID WP_000813794.1
Coordinates 2983951..2984127 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NAG72_RS14350 Protein ID WP_001270286.1
Coordinates 2983489..2983905 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG72_RS14330 (2978641) 2978641..2979582 - 942 WP_001251304.1 ABC transporter permease -
NAG72_RS14335 (2979583) 2979583..2980596 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
NAG72_RS14340 (2980614) 2980614..2981759 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
NAG72_RS14345 (2982004) 2982004..2983410 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
NAG72_RS14350 (2983489) 2983489..2983905 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NAG72_RS14355 (2983951) 2983951..2984127 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NAG72_RS14360 (2984349) 2984349..2984579 + 231 WP_000494244.1 YncJ family protein -
NAG72_RS14365 (2984671) 2984671..2986632 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NAG72_RS14370 (2986705) 2986705..2987241 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
NAG72_RS14375 (2987294) 2987294..2988508 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T246502 WP_000813794.1 NZ_CP097884:c2984127-2983951 [Escherichia coli str. K-12 substr. MG1655]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT246502 WP_001270286.1 NZ_CP097884:c2983905-2983489 [Escherichia coli str. K-12 substr. MG1655]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References