Detailed information of TA system TA024649

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 2495251..2495986
• Replicon: chromosome
• Accession: NC_013956
• Organism: Pantoea ananatis LMG 20103

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: PANA_RS11380
• Protein ID: WP_041457680.1
• Coordinates: 2495594..2495986 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: PANA_RS11375
• Protein ID: WP_013026116.1
• Coordinates: 2495251..2495604 (-)
• Length: 118 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PANA_RS11355	2491882..2492568	+	687	WP_013026113.1	two-component system response regulator PmrA	-
PANA_RS11360	2492565..2493632	+	1068	WP_013026114.1	two-component system sensor histidine kinase PmrB	-
PANA_RS11365	2493995..2494534	+	540	WP_013026115.1	peptide-methionine (S)-S-oxide reductase MsrA	-
PANA_RS11375	2495251..2495604	-	354	WP_013026116.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
PANA_RS11380	2495594..2495986	-	393	WP_041457680.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PANA_RS11385	2496311..2497258	-	948	WP_041457681.1	sulfonate ABC transporter substrate-binding protein	-
PANA_RS11390	2497353..2499239	-	1887	WP_026020924.1	aliphatic sulfonate ABC transporter substrate-binding protein	-
PANA_RS11395	2499518..2500690	+	1173	WP_013026120.1	FMNH2-dependent alkanesulfonate monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (6-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (56-99)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 15039.34 Da
• Isoelectric Point: 10.0216

>T24649 WP_041457680.1 NC_013956:c2495986-2495594 [Pantoea ananatis LMG 20103]
MGFTLYVHKRFDRVFKKTRLTDSVLCYAEGDVITGVFEADLGGGVIKKRLALHQGKRGGVRTVIFFRQGTNLVYYDGWVK
NLSRKYAREIDEDQLDTYRDVARMFFRANSEVMSLLVRSGMVREVKCNEN

Nucleotide

• Length: 393 bp

>T24649 NC_013956:c2495986-2495594 [Pantoea ananatis LMG 20103]
ATGGGTTTTACGCTTTATGTTCATAAACGTTTTGACAGAGTGTTTAAAAAAACGCGTCTGACAGACAGCGTCCTGTGTTA
CGCAGAAGGTGACGTTATTACTGGCGTGTTTGAGGCTGACTTAGGCGGTGGCGTTATTAAAAAGCGTCTTGCTCTTCACC
AAGGCAAGCGTGGCGGCGTGCGAACGGTCATCTTCTTCAGACAAGGCACCAACCTGGTTTATTACGATGGATGGGTTAAA
AACTTGTCGAGGAAATACGCCAGGGAAATCGATGAAGATCAGCTGGATACCTACAGGGATGTGGCAAGAATGTTTTTCCG
TGCAAATAGTGAAGTGATGAGCCTGCTCGTCAGAAGCGGAATGGTCAGAGAGGTTAAATGTAATGAAAACTGA

Antitoxin

Protein

• Length: 118 a.a.
• Molecular weight: 13097.13 Da
• Isoelectric Point: 6.4825

>AT24649 WP_013026116.1 NC_013956:c2495604-2495251 [Pantoea ananatis LMG 20103]
MKTEPAELSELLEDAKAFHALGLATDEEVESIAKRAKNRELRARIASVKPMTATEIKDVRMRWGMSQSLVALSFGMTVDS
VSKWERGEITPSPPVMRMLQLLRDNGPELFTSKHEGI

Nucleotide

• Length: 354 bp

>AT24649 NC_013956:c2495604-2495251 [Pantoea ananatis LMG 20103]
ATGAAAACTGAACCCGCCGAATTGAGTGAACTACTTGAAGATGCGAAAGCGTTTCACGCGTTAGGACTGGCAACAGATGA
AGAAGTGGAGTCCATAGCAAAGCGCGCAAAAAATCGTGAACTCCGTGCCCGTATTGCATCAGTAAAGCCCATGACAGCAA
CTGAAATCAAAGACGTGCGCATGCGTTGGGGAATGTCGCAATCGCTTGTGGCGCTCTCATTTGGCATGACGGTCGATAGC
GTATCGAAATGGGAGCGAGGTGAAATCACACCGAGCCCACCGGTGATGCGGATGCTGCAACTCCTTCGCGATAACGGCCC
TGAACTCTTTACCTCTAAGCATGAAGGTATCTAG