Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4023641..4024455 Replicon chromosome
Accession NZ_CP097883
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag NAG71_RS19695 Protein ID WP_001054376.1
Coordinates 4023641..4023898 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag NAG71_RS19700 Protein ID WP_001309181.1
Coordinates 4023910..4024455 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG71_RS19670 (4018929) 4018929..4020035 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
NAG71_RS19675 (4020100) 4020100..4021080 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
NAG71_RS19680 (4021190) 4021190..4021395 + 206 Protein_3843 HNH endonuclease -
NAG71_RS19685 (4021663) 4021663..4022903 - 1241 Protein_3844 helicase YjhR -
NAG71_RS19690 (4023019) 4023019..4023150 + 132 WP_001309182.1 hypothetical protein -
NAG71_RS19695 (4023641) 4023641..4023898 + 258 WP_001054376.1 YjhX family toxin Toxin
NAG71_RS19700 (4023910) 4023910..4024455 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
NAG71_RS19705 (4024511) 4024511..4025257 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
NAG71_RS19710 (4025426) 4025426..4025644 + 219 Protein_3849 hypothetical protein -
NAG71_RS19715 (4025682) 4025682..4025798 + 117 Protein_3850 VOC family protein -
NAG71_RS19720 (4026043) 4026043..4027164 + 1122 WP_000010829.1 M42 family metallopeptidase -
NAG71_RS19725 (4027161) 4027161..4027439 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
NAG71_RS19730 (4027451) 4027451..4028764 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4016135..4032679 16544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T246482 WP_001054376.1 NZ_CP097883:4023641-4023898 [Escherichia coli str. K-12 substr. MG1655]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT246482 WP_001309181.1 NZ_CP097883:4023910-4024455 [Escherichia coli str. K-12 substr. MG1655]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References