Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3436111..3436729 Replicon chromosome
Accession NZ_CP097883
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NAG71_RS16835 Protein ID WP_001291435.1
Coordinates 3436511..3436729 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NAG71_RS16830 Protein ID WP_000344800.1
Coordinates 3436111..3436485 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG71_RS16820 (3431200) 3431200..3432393 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NAG71_RS16825 (3432416) 3432416..3435565 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NAG71_RS16830 (3436111) 3436111..3436485 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NAG71_RS16835 (3436511) 3436511..3436729 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NAG71_RS16840 (3436901) 3436901..3437452 + 552 WP_000102564.1 maltose O-acetyltransferase -
NAG71_RS16845 (3437568) 3437568..3438038 + 471 WP_000136192.1 YlaC family protein -
NAG71_RS16850 (3438202) 3438202..3439752 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NAG71_RS16855 (3439794) 3439794..3440147 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NAG71_RS16865 (3440526) 3440526..3440837 + 312 WP_000409911.1 MGMT family protein -
NAG71_RS16870 (3440868) 3440868..3441440 - 573 WP_000779842.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T246476 WP_001291435.1 NZ_CP097883:3436511-3436729 [Escherichia coli str. K-12 substr. MG1655]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT246476 WP_000344800.1 NZ_CP097883:3436111-3436485 [Escherichia coli str. K-12 substr. MG1655]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References