Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3436111..3436729 | Replicon | chromosome |
Accession | NZ_CP097883 | ||
Organism | Escherichia coli str. K-12 substr. MG1655 strain K-12 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | H5UYE2 |
Locus tag | NAG71_RS16835 | Protein ID | WP_001291435.1 |
Coordinates | 3436511..3436729 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | S1PTH5 |
Locus tag | NAG71_RS16830 | Protein ID | WP_000344800.1 |
Coordinates | 3436111..3436485 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NAG71_RS16820 (3431200) | 3431200..3432393 | + | 1194 | WP_001295324.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
NAG71_RS16825 (3432416) | 3432416..3435565 | + | 3150 | WP_001132469.1 | efflux RND transporter permease AcrB | - |
NAG71_RS16830 (3436111) | 3436111..3436485 | + | 375 | WP_000344800.1 | Hha toxicity modulator TomB | Antitoxin |
NAG71_RS16835 (3436511) | 3436511..3436729 | + | 219 | WP_001291435.1 | HHA domain-containing protein | Toxin |
NAG71_RS16840 (3436901) | 3436901..3437452 | + | 552 | WP_000102564.1 | maltose O-acetyltransferase | - |
NAG71_RS16845 (3437568) | 3437568..3438038 | + | 471 | WP_000136192.1 | YlaC family protein | - |
NAG71_RS16850 (3438202) | 3438202..3439752 | + | 1551 | WP_001310610.1 | cyclic-guanylate-specific phosphodiesterase PdeB | - |
NAG71_RS16855 (3439794) | 3439794..3440147 | - | 354 | WP_000878140.1 | DUF1428 domain-containing protein | - |
NAG71_RS16865 (3440526) | 3440526..3440837 | + | 312 | WP_000409911.1 | MGMT family protein | - |
NAG71_RS16870 (3440868) | 3440868..3441440 | - | 573 | WP_000779842.1 | YbaY family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T246476 WP_001291435.1 NZ_CP097883:3436511-3436729 [Escherichia coli str. K-12 substr. MG1655]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
Antitoxin
Download Length: 125 a.a. Molecular weight: 14557.39 Da Isoelectric Point: 4.7395
>AT246476 WP_000344800.1 NZ_CP097883:3436111-3436485 [Escherichia coli str. K-12 substr. MG1655]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
Download Length: 375 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 2MW2 | |
PDB | 1JW2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QBQ5 |