Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4108652..4109247 Replicon chromosome
Accession NZ_CP097882
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag NAG70_RS20120 Protein ID WP_000239577.1
Coordinates 4108652..4109002 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag NAG70_RS20125 Protein ID WP_001223208.1
Coordinates 4108996..4109247 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG70_RS20100 (4104098) 4104098..4105120 - 1023 WP_001313531.1 ABC transporter permease -
NAG70_RS20105 (4105134) 4105134..4106636 - 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
NAG70_RS20110 (4106776) 4106776..4107732 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NAG70_RS20115 (4108042) 4108042..4108572 + 531 WP_000055075.1 inorganic diphosphatase -
NAG70_RS20120 (4108652) 4108652..4109002 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
NAG70_RS20125 (4108996) 4108996..4109247 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NAG70_RS20130 (4109459) 4109459..4109800 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NAG70_RS20135 (4109803) 4109803..4113582 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T246457 WP_000239577.1 NZ_CP097882:c4109002-4108652 [Escherichia coli str. K-12 substr. MG1655]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT246457 WP_001223208.1 NZ_CP097882:c4109247-4108996 [Escherichia coli str. K-12 substr. MG1655]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References