Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2358074..2358712 Replicon chromosome
Accession NZ_CP097882
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NAG70_RS11415 Protein ID WP_000813794.1
Coordinates 2358536..2358712 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NAG70_RS11410 Protein ID WP_001270286.1
Coordinates 2358074..2358490 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG70_RS11390 (2353226) 2353226..2354167 - 942 WP_001251304.1 ABC transporter permease -
NAG70_RS11395 (2354168) 2354168..2355181 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
NAG70_RS11400 (2355199) 2355199..2356344 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
NAG70_RS11405 (2356589) 2356589..2357995 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
NAG70_RS11410 (2358074) 2358074..2358490 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NAG70_RS11415 (2358536) 2358536..2358712 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NAG70_RS11420 (2358934) 2358934..2359164 + 231 WP_000494244.1 YncJ family protein -
NAG70_RS11425 (2359256) 2359256..2361217 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NAG70_RS11430 (2361290) 2361290..2361826 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
NAG70_RS11435 (2361918) 2361918..2363093 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T246449 WP_000813794.1 NZ_CP097882:c2358712-2358536 [Escherichia coli str. K-12 substr. MG1655]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT246449 WP_001270286.1 NZ_CP097882:c2358490-2358074 [Escherichia coli str. K-12 substr. MG1655]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References