Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4037853..4038448 Replicon chromosome
Accession NZ_CP097881
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag NAG69_RS19650 Protein ID WP_000239577.1
Coordinates 4037853..4038203 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag NAG69_RS19655 Protein ID WP_001223208.1
Coordinates 4038197..4038448 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG69_RS19630 (4033299) 4033299..4034321 - 1023 WP_001313531.1 ABC transporter permease -
NAG69_RS19635 (4034335) 4034335..4035837 - 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
NAG69_RS19640 (4035977) 4035977..4036933 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NAG69_RS19645 (4037243) 4037243..4037773 + 531 WP_000055075.1 inorganic diphosphatase -
NAG69_RS19650 (4037853) 4037853..4038203 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
NAG69_RS19655 (4038197) 4038197..4038448 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NAG69_RS19660 (4038660) 4038660..4039001 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NAG69_RS19665 (4039004) 4039004..4042783 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T246431 WP_000239577.1 NZ_CP097881:c4038203-4037853 [Escherichia coli str. K-12 substr. MG1655]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT246431 WP_001223208.1 NZ_CP097881:c4038448-4038197 [Escherichia coli str. K-12 substr. MG1655]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References