Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3952842..3953656 Replicon chromosome
Accession NZ_CP097881
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag NAG69_RS19220 Protein ID WP_001054376.1
Coordinates 3952842..3953099 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag NAG69_RS19225 Protein ID WP_001309181.1
Coordinates 3953111..3953656 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG69_RS19195 (3948130) 3948130..3949236 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
NAG69_RS19200 (3949301) 3949301..3950281 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
NAG69_RS19205 (3950391) 3950391..3950596 + 206 Protein_3748 HNH endonuclease -
NAG69_RS19210 (3950864) 3950864..3952104 - 1241 Protein_3749 helicase YjhR -
NAG69_RS19215 (3952220) 3952220..3952351 + 132 WP_001309182.1 hypothetical protein -
NAG69_RS19220 (3952842) 3952842..3953099 + 258 WP_001054376.1 YjhX family toxin Toxin
NAG69_RS19225 (3953111) 3953111..3953656 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
NAG69_RS19230 (3953712) 3953712..3954458 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
NAG69_RS19235 (3954627) 3954627..3954845 + 219 Protein_3754 hypothetical protein -
NAG69_RS19240 (3954883) 3954883..3954999 + 117 Protein_3755 VOC family protein -
NAG69_RS19245 (3955244) 3955244..3956365 + 1122 WP_000010829.1 M42 family metallopeptidase -
NAG69_RS19250 (3956362) 3956362..3956640 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
NAG69_RS19255 (3956652) 3956652..3957965 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 3942628..3961880 19252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T246430 WP_001054376.1 NZ_CP097881:3952842-3953099 [Escherichia coli str. K-12 substr. MG1655]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT246430 WP_001309181.1 NZ_CP097881:3953111-3953656 [Escherichia coli str. K-12 substr. MG1655]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References