Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3362763..3363381 Replicon chromosome
Accession NZ_CP097881
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NAG69_RS16350 Protein ID WP_001291435.1
Coordinates 3363163..3363381 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NAG69_RS16345 Protein ID WP_000344800.1
Coordinates 3362763..3363137 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG69_RS16335 (3357852) 3357852..3359045 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NAG69_RS16340 (3359068) 3359068..3362217 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NAG69_RS16345 (3362763) 3362763..3363137 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NAG69_RS16350 (3363163) 3363163..3363381 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NAG69_RS16355 (3363553) 3363553..3364104 + 552 WP_000102564.1 maltose O-acetyltransferase -
NAG69_RS16360 (3364220) 3364220..3364690 + 471 WP_000136192.1 YlaC family protein -
NAG69_RS16365 (3364854) 3364854..3366404 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NAG69_RS16370 (3366446) 3366446..3366799 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NAG69_RS16380 (3367178) 3367178..3367489 + 312 WP_000409911.1 MGMT family protein -
NAG69_RS16385 (3367520) 3367520..3368092 - 573 WP_000779842.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T246424 WP_001291435.1 NZ_CP097881:3363163-3363381 [Escherichia coli str. K-12 substr. MG1655]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT246424 WP_000344800.1 NZ_CP097881:3362763-3363137 [Escherichia coli str. K-12 substr. MG1655]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References