Detailed information of TA system TA246407

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2693431..2695259
• Replicon: chromosome
• Accession: NZ_CP097873
• Organism: Vibrio parahaemolyticus strain GL-601

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: NAG75_RS13590
• Protein ID: WP_165386962.1
• Coordinates: 2693431..2694792 (+)
• Length: 454 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: NAG75_RS13595
• Protein ID: WP_130349326.1
• Coordinates: 2694777..2695259 (+)
• Length: 161 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NAG75_RS13580	2691193..2691579	+	387	WP_208893604.1	transcriptional regulator	-
NAG75_RS13585	2692146..2692940	+	795	WP_130349328.1	metallophosphoesterase	-
NAG75_RS13590	2693431..2694792	+	1362	WP_165386962.1	type II toxin-antitoxin system HipA family toxin	Toxin
NAG75_RS13595	2694777..2695259	+	483	WP_130349326.1	helix-turn-helix domain-containing protein	Antitoxin
NAG75_RS13600	2695737..2695913	+	177	Protein_2416	lipase family protein	-
NAG75_RS13605	2696050..2696613	-	564	WP_005455971.1	porin family protein	-
NAG75_RS13610	2697014..2697904	+	891	WP_025502364.1	LysR family transcriptional regulator	-
NAG75_RS13615	2698040..2699572	+	1533	WP_208893603.1	bifunctional GNAT family N-acetyltransferase/carbon-nitrogen hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2671349..2709542	38193

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-385)

Antitoxin

• Cro/C1-type helix-turn-helix domain (88-139)

Sequences

Toxin

Protein

• Length: 454 a.a.
• Molecular weight: 51398.09 Da
• Isoelectric Point: 4.8182

>T246407 WP_165386962.1 NZ_CP097873:2693431-2694792 [Vibrio parahaemolyticus]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHHDKDDFHAVSLNHPVSFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQINEQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPVYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEVLLQELEVTASKCIDLKQRLALRGVPEQILEMPAVGLNHISEKLTKWGLL

Nucleotide

• Length: 1362 bp

Antitoxin

Protein

• Length: 161 a.a.
• Molecular weight: 17534.07 Da
• Isoelectric Point: 10.9400

>AT246407 WP_130349326.1 NZ_CP097873:2694777-2695259 [Vibrio parahaemolyticus]
MGATMNKPSNKESVQDTVARLRANRNQHQPKTGTNATHSTKERSQLNTPTRSKTSKNAKAVSAAERKTEANKIIKHLLLG
ELTQGQALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGMLPSSPDVLKSLLIDGEAG

Nucleotide

• Length: 483 bp