Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/GNAT-DUF1778
Location 3689185..3689966 Replicon chromosome
Accession NZ_CP097870
Organism Thauera sp. GDN1

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag CKCBHOJB_RS16995 Protein ID WP_281049850.1
Coordinates 3689185..3689691 (-) Length 169 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag CKCBHOJB_RS17000 Protein ID WP_281049851.1
Coordinates 3689688..3689966 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKCBHOJB_RS16975 (CKCBHOJB_03396) 3684799..3685860 + 1062 WP_281049846.1 glycosyltransferase family 10 -
CKCBHOJB_RS16980 (CKCBHOJB_03397) 3685875..3686882 - 1008 WP_281049847.1 glycosyltransferase family 10 -
CKCBHOJB_RS16985 (CKCBHOJB_03398) 3687021..3688142 + 1122 WP_281049848.1 GDP-mannose 4,6-dehydratase -
CKCBHOJB_RS16990 (CKCBHOJB_03399) 3688183..3689151 + 969 WP_281049849.1 GDP-L-fucose synthase -
CKCBHOJB_RS16995 (CKCBHOJB_03400) 3689185..3689691 - 507 WP_281049850.1 GNAT family N-acetyltransferase Toxin
CKCBHOJB_RS17000 (CKCBHOJB_03401) 3689688..3689966 - 279 WP_281049851.1 DUF1778 domain-containing protein Antitoxin
CKCBHOJB_RS17005 (CKCBHOJB_03402) 3690197..3691042 + 846 WP_281049852.1 Wzz/FepE/Etk N-terminal domain-containing protein -
CKCBHOJB_RS17010 (CKCBHOJB_03403) 3691048..3692085 + 1038 WP_281049853.1 hypothetical protein -
CKCBHOJB_RS17015 (CKCBHOJB_03404) 3692172..3693236 + 1065 WP_281049854.1 dTDP-glucose 4,6-dehydratase -
CKCBHOJB_RS17020 (CKCBHOJB_03405) 3693239..3694123 + 885 WP_281051715.1 glucose-1-phosphate thymidylyltransferase RfbA -
CKCBHOJB_RS17025 3694120..3694701 + 582 WP_281049855.1 dTDP-4-dehydrorhamnose 3,5-epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - gmd / fcl 3483069..3707240 224171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(43-146)

Antitoxin

Vibrio phage ICP1, Orf50

(5-87)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 18317.12 Da        Isoelectric Point: 6.9490

>T246402 WP_281049850.1 NZ_CP097870:c3689691-3689185 [Thauera sp. GDN1]
MSAAYEPVRKLSAEDSVEAFECGHPALDQFLQRYALVNQKANSAQTYVCCRGGEVVGFYSLAVGGVDPEDAPARAVKGLA
RHPVPVMILARLAVDKDHQGRGLGKALLKDALLRTAQAADIAGIRCLLVHAKDEAARQWYVSWEFEPSPTDPYHLFLMVK
DLKALLVA

Download         Length: 507 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10208.61 Da        Isoelectric Point: 8.0530

>AT246402 WP_281049851.1 NZ_CP097870:c3689966-3689688 [Thauera sp. GDN1]
MSALNPSKTERIDVRASSAVKQLLQEAARSCHKNVSEFLLDAGVTAANQALADRRHFVLNDEEWQAFQQALDRPVQAKPR
LKKLLGEPGVLD

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References