Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3676876..3677516 Replicon chromosome
Accession NZ_CP097870
Organism Thauera sp. GDN1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CKCBHOJB_RS16925 Protein ID WP_281049836.1
Coordinates 3677118..3677516 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CKCBHOJB_RS16920 Protein ID WP_281049835.1
Coordinates 3676876..3677115 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKCBHOJB_RS16900 (CKCBHOJB_03381) 3673782..3674330 + 549 WP_281049831.1 bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase -
CKCBHOJB_RS16905 (CKCBHOJB_03382) 3674365..3674961 + 597 WP_281049832.1 Uma2 family endonuclease -
CKCBHOJB_RS16910 (CKCBHOJB_03383) 3674980..3676038 + 1059 WP_281049833.1 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase -
CKCBHOJB_RS16915 (CKCBHOJB_03384) 3676060..3676827 + 768 WP_281049834.1 adenosylcobinamide-GDP ribazoletransferase -
CKCBHOJB_RS16920 (CKCBHOJB_03385) 3676876..3677115 + 240 WP_281049835.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CKCBHOJB_RS16925 (CKCBHOJB_03386) 3677118..3677516 + 399 WP_281049836.1 tRNA(fMet)-specific endonuclease VapC Toxin
CKCBHOJB_RS16930 (CKCBHOJB_03387) 3677546..3678244 + 699 WP_281049837.1 alpha-ribazole phosphatase family protein -
CKCBHOJB_RS16935 (CKCBHOJB_03388) 3678392..3679294 + 903 WP_281049838.1 mitochondrial fission ELM1 family protein -
CKCBHOJB_RS16940 (CKCBHOJB_03389) 3679563..3680156 + 594 WP_281049839.1 Uma2 family endonuclease -
CKCBHOJB_RS16945 (CKCBHOJB_03390) 3680252..3680524 + 273 WP_281049840.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
CKCBHOJB_RS16950 (CKCBHOJB_03391) 3680502..3680822 + 321 WP_281049841.1 type II toxin-antitoxin system YafQ family toxin -
CKCBHOJB_RS16955 (CKCBHOJB_03392) 3680830..3681963 + 1134 WP_281049842.1 glycosyltransferase family 4 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - gmd / fcl 3483069..3707240 224171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14739.89 Da        Isoelectric Point: 9.5289

>T246401 WP_281049836.1 NZ_CP097870:3677118-3677516 [Thauera sp. GDN1]
MLKYLLDTNIVIYTVKNKPAQVRERFRQHGGQMAISSVTLGELVFGAERSTRPEANLAVVEGFVARVDTLDFDPAAAHHF
GQIRAELYRAGRPIGPYDMMIAAHARSRGLILVTNNTSEFERVAGLRLENWA

Download         Length: 399 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8711.78 Da        Isoelectric Point: 4.6721

>AT246401 WP_281049835.1 NZ_CP097870:3676876-3677115 [Thauera sp. GDN1]
MTSSSQTTVFRSNKTQAVRLPKALELPESVKKVTITAIGNTRVIAPVEASWDAWFDGPDVSADFMVAREQPDDQAREAF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References