Detailed information of TA system TA024640

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2179571..2180919
• Replicon: chromosome
• Accession: NC_013956
• Organism: Pantoea ananatis LMG 20103

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: D4GEZ5
• Locus tag: PANA_RS09935
• Protein ID: WP_013025827.1
• Coordinates: 2179571..2180680 (-)
• Length: 370 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: PANA_RS09940
• Protein ID: WP_013025828.1
• Coordinates: 2180680..2180919 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PANA_RS09925	2176789..2178657	+	1869	WP_013025825.1	low affinity potassium transporter Kup	-
PANA_RS09930	2179109..2179525	+	417	WP_013025826.1	GFA family protein	-
PANA_RS09935	2179571..2180680	-	1110	WP_013025827.1	HipA domain-containing protein	Toxin
PANA_RS09940	2180680..2180919	-	240	WP_013025828.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
PANA_RS09945	2181034..2181477	+	444	WP_013025829.1	GNAT family N-acetyltransferase	-
PANA_RS09950	2181541..2183916	-	2376	WP_013025830.1	glycoside hydrolase family 3 C-terminal domain-containing protein	-
PANA_RS09955	2183939..2185327	-	1389	WP_041457652.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (132-328)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-63)

Sequences

Toxin

Protein

• Length: 370 a.a.
• Molecular weight: 40849.19 Da
• Isoelectric Point: 7.4556

>T24640 WP_013025827.1 NC_013956:c2180680-2179571 [Pantoea ananatis LMG 20103]
MAKLIAWINGERTGTLTLHHNGALHFQYDANWLQHPLARPLSLSLPLQRAAMHSEKVVHFFENLLFPSALIEKDFYPTHP
IKSCEVFAALQKVGHTLPGALSLLPAKRQPVAPDQATHSVFSPADEAQQFDIDNAYLCLSLARELTIPVPDAVLVHENGI
RKLRTERYDRRWRHDGQHLYHLPEEDVCQALGVPLSGRDEQQGGPGIDDIMALLMGSSSAMKDREDLMRCMVFQWLTGIT
RVNAKHLSLLIARGGSFRLAPFKHLLSACPGLSLRTTDRRDFQLGMGLTGPEGKQHHIDAIGPAHFLALAGSVGFSQAAM
RQILAAFVPGLPAAIVKVRDSLPDDYPLTLADAVFSHAMMMLERVRQAI

Nucleotide

• Length: 1110 bp

>T24640 NC_013956:c2180680-2179571 [Pantoea ananatis LMG 20103]
ATGGCAAAGCTCATTGCCTGGATAAACGGCGAGCGTACGGGAACGCTGACGCTGCATCACAACGGCGCGCTGCATTTCCA
GTATGACGCCAACTGGCTTCAGCATCCGCTTGCCAGACCTCTCTCGCTTTCGTTGCCCTTACAGCGCGCCGCGATGCATT
CTGAGAAAGTCGTGCACTTTTTCGAAAACCTTCTCTTTCCCAGTGCGTTGATCGAAAAGGATTTTTACCCCACTCACCCG
ATAAAATCCTGTGAGGTGTTTGCAGCATTGCAGAAAGTGGGACACACATTGCCCGGGGCGCTCAGTCTGCTGCCGGCAAA
GCGGCAGCCCGTCGCGCCGGACCAGGCAACGCACAGCGTCTTCAGCCCCGCCGATGAGGCACAGCAGTTCGATATCGATA
ATGCGTATCTGTGTCTGTCCCTGGCCCGGGAGCTAACTATCCCGGTGCCGGATGCCGTGTTAGTTCATGAGAACGGCATC
CGTAAATTGAGAACAGAACGATACGATCGCCGTTGGCGTCACGACGGACAACACCTTTATCATCTTCCTGAAGAAGACGT
GTGTCAGGCGCTCGGCGTGCCGCTCTCTGGCCGCGATGAGCAGCAGGGCGGTCCGGGAATTGATGACATCATGGCCTTGC
TGATGGGCTCAAGCTCCGCCATGAAAGACCGTGAGGATCTGATGCGCTGTATGGTATTTCAGTGGCTGACGGGCATCACG
CGCGTCAACGCTAAACATCTTTCGCTGCTGATTGCTCGCGGTGGCAGCTTCCGGCTCGCGCCTTTTAAGCATCTCCTTTC
CGCCTGCCCGGGCCTTTCTCTACGCACAACAGACAGACGGGATTTCCAGCTGGGGATGGGCCTGACAGGCCCTGAGGGCA
AACAGCATCACATTGACGCGATTGGGCCCGCGCATTTTCTTGCCCTTGCGGGGAGCGTGGGGTTCAGTCAGGCAGCGATG
CGGCAGATACTCGCGGCCTTTGTTCCGGGCTTGCCTGCCGCGATTGTTAAGGTGCGGGACAGCCTGCCCGATGATTATCC
CCTGACGCTCGCCGATGCGGTTTTCAGCCACGCAATGATGATGCTGGAAAGGGTGCGCCAGGCGATCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8746.94 Da
• Isoelectric Point: 7.2012

>AT24640 WP_013025828.1 NC_013956:c2180919-2180680 [Pantoea ananatis LMG 20103]
MIYSPRQLANQVRLLRQQNGWTQVELAKKVGLKQATLSHFENAPDTTSLATLFKILQALDLALSLHENSASSAPAEDAW

Nucleotide

• Length: 240 bp

>AT24640 NC_013956:c2180919-2180680 [Pantoea ananatis LMG 20103]
ATGATTTACAGTCCCCGCCAGTTGGCGAATCAGGTCAGGCTATTGCGGCAGCAAAACGGCTGGACCCAGGTCGAACTGGC
GAAAAAAGTGGGCCTGAAACAGGCAACCCTGTCTCACTTCGAAAATGCCCCGGATACAACCTCACTGGCAACGTTGTTCA
AAATCTTACAGGCGCTCGATCTTGCTCTGTCGCTTCATGAAAACAGCGCATCCTCAGCCCCGGCTGAGGATGCCTGGTAA

Structures

Toxin

• AlphaFold DB: D4GEZ5