Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2509979..2511524 Replicon chromosome
Accession NZ_CP097870
Organism Thauera sp. GDN1

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag CKCBHOJB_RS11570 Protein ID WP_281048821.1
Coordinates 2510229..2511524 (+) Length 432 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag CKCBHOJB_RS11565 Protein ID WP_281048820.1
Coordinates 2509979..2510239 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKCBHOJB_RS11535 (CKCBHOJB_02296) 2505045..2505695 - 651 WP_281048814.1 hypothetical protein -
CKCBHOJB_RS11540 (CKCBHOJB_02297) 2505692..2506363 - 672 WP_281048815.1 SCO family protein -
CKCBHOJB_RS11545 (CKCBHOJB_02298) 2506363..2506815 - 453 WP_281048816.1 group III truncated hemoglobin -
CKCBHOJB_RS11550 (CKCBHOJB_02299) 2506822..2507415 - 594 WP_281048817.1 cytochrome c -
CKCBHOJB_RS11555 (CKCBHOJB_02300) 2507432..2508022 - 591 WP_281048818.1 cbb3-type cytochrome c oxidase subunit II -
CKCBHOJB_RS11560 (CKCBHOJB_02301) 2508022..2509623 - 1602 WP_281048819.1 cbb3-type cytochrome c oxidase subunit I -
CKCBHOJB_RS11565 (CKCBHOJB_02302) 2509979..2510239 + 261 WP_281048820.1 helix-turn-helix transcriptional regulator Antitoxin
CKCBHOJB_RS11570 (CKCBHOJB_02303) 2510229..2511524 + 1296 WP_281048821.1 type II toxin-antitoxin system HipA family toxin Toxin
CKCBHOJB_RS11575 (CKCBHOJB_02304) 2511644..2513989 + 2346 WP_281048822.1 DEAD/DEAH box helicase family protein -
CKCBHOJB_RS11580 (CKCBHOJB_02305) 2514157..2515626 + 1470 WP_281048823.1 class I SAM-dependent DNA methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(147-379)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-62)


Sequences

Toxin        


Download         Length: 432 a.a.        Molecular weight: 47130.15 Da        Isoelectric Point: 7.6965

>T246398 WP_281048821.1 NZ_CP097870:2510229-2511524 [Thauera sp. GDN1]
MTHELEVWLFSEHVGTLALVDGRLGFCYAPGWLSRPNAVALSHSLPLRAQPFDDRATRPFFAGLLPEGQMRRLIARQFQV
SGQNDFALLDHIGGECAGAVTFLAPGQSLPTPAQTGAVRWLSDDEVVAVLDELPRRPMLAGKDGLRLSLAGAQDKLPVVF
DGTRLGLPLNGTPSSHILKPPVHGVEDSVINEGFCMALAEALQLEPAKASIYAVLNRPFLLVDRYDRVLDAKGCRQRLHQ
EDFCQALGVVPEMKYQNEGGPDLAQCFDLVRRATRPSAPQVLRLFDYVIFNALIGNHDAHAKNFSLLYAGRTPILAPLYD
TLSTAVYPTLTPKMAMKIGSKYKFSEVEARHWEQLAEGAGLAKAPARRRILELANSLPRAARALQSDRARGFAGNGVVES
IVALIEQRCALTLRRLSAPASRDEEGFASPQ

Download         Length: 1296 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 8844.02 Da        Isoelectric Point: 4.9556

>AT246398 WP_281048820.1 NZ_CP097870:2509979-2510239 [Thauera sp. GDN1]
MTSISSAQQLGDALRAARKQLGLTQPQLALAAGVGVRFIVDLEAGKPTVRLENVLRVIDALGGELQLSGLPTAEADHATE
GSGHDA

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References