Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1342018..1342808 Replicon chromosome
Accession NZ_CP097870
Organism Thauera sp. GDN1

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag CKCBHOJB_RS06055 Protein ID WP_281051107.1
Coordinates 1342308..1342808 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag CKCBHOJB_RS06050 Protein ID WP_281051106.1
Coordinates 1342018..1342311 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKCBHOJB_RS06025 (CKCBHOJB_01207) 1337313..1338188 + 876 WP_281051102.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD -
CKCBHOJB_RS06030 (CKCBHOJB_01208) 1338199..1338690 + 492 WP_281051103.1 5-(carboxyamino)imidazole ribonucleotide mutase -
CKCBHOJB_RS06035 (CKCBHOJB_01209) 1338701..1339855 + 1155 WP_281051104.1 5-(carboxyamino)imidazole ribonucleotide synthase -
CKCBHOJB_RS06040 (CKCBHOJB_01210) 1339866..1340978 + 1113 WP_281051105.1 L-threonylcarbamoyladenylate synthase -
CKCBHOJB_RS06050 (CKCBHOJB_01212) 1342018..1342311 + 294 WP_281051106.1 DUF1778 domain-containing protein Antitoxin
CKCBHOJB_RS06055 (CKCBHOJB_01213) 1342308..1342808 + 501 WP_281051107.1 GNAT family N-acetyltransferase Toxin
CKCBHOJB_RS06060 (CKCBHOJB_01214) 1342873..1343790 - 918 WP_281051108.1 helix-turn-helix domain-containing protein -
CKCBHOJB_RS06065 (CKCBHOJB_01215) 1343922..1344374 - 453 WP_281051109.1 site-specific recombinase resolvase -
CKCBHOJB_RS06070 1344401..1344760 - 360 WP_281051110.1 hypothetical protein -
CKCBHOJB_RS06075 1344750..1345106 + 357 Protein_1189 transposase -
CKCBHOJB_RS06080 1345089..1345430 + 342 WP_281051632.1 CoA transferase -
CKCBHOJB_RS06085 (CKCBHOJB_01218) 1345488..1345661 + 174 WP_281051111.1 hypothetical protein -
CKCBHOJB_RS06090 (CKCBHOJB_01219) 1345859..1346146 + 288 WP_281051112.1 hypothetical protein -
CKCBHOJB_RS06095 (CKCBHOJB_01220) 1346523..1347743 + 1221 WP_281051113.1 RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-90)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18353.33 Da        Isoelectric Point: 9.6009

>T246397 WP_281051107.1 NZ_CP097870:1342308-1342808 [Thauera sp. GDN1]
MSLRGPESLGLQHRLEGFDCGKPALNDWLLCHARQAQGSGSAKTFVVADDDRVAGYFSLTVGQIDTLEAPERIRKGMGQY
PLPVVILARLAVSKQDRGRGIGFGLLQDAIRRTMLIAEQAGIRAMLTHPIDEEAAKFYTRFGFIASPLREQQLLLLLKDA
RKFVMA

Download         Length: 501 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10697.18 Da        Isoelectric Point: 4.7527

>AT246397 WP_281051106.1 NZ_CP097870:1342018-1342311 [Thauera sp. GDN1]
MVAVASSPAARSARLGLRATPEQEVVLRRAAEVAHKSLTDFILDSACLAAEQTLLDQRLFMVTGSQYQALMDLLDQPEQP
NEGLRDLFSRKAPWDQA

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References