Detailed information of TA system TA246394

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 2093913..2095260
• Replicon: chromosome
• Accession: NZ_CP097859
• Organism: Vibrio owensii strain GL-605

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: M8C01_RS26730
• Protein ID: WP_122045120.1
• Coordinates: 2093913..2094854 (-)
• Length: 314 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: M8C01_RS26735
• Protein ID: WP_122045119.1
• Coordinates: 2094856..2095260 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M8C01_RS26715	2090264..2091100	-	837	WP_122045122.1	hypothetical protein	-
M8C01_RS26720	2091166..2092386	-	1221	WP_162998338.1	restriction endonuclease subunit S	-
M8C01_RS26725	2092376..2093893	-	1518	WP_122045121.1	type I restriction-modification system subunit M	-
M8C01_RS26730	2093913..2094854	-	942	WP_122045120.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
M8C01_RS26735	2094856..2095260	-	405	WP_122045119.1	DUF6088 family protein	Antitoxin
M8C01_RS26740	2095449..2096042	-	594	WP_085343577.1	tyrosine-type recombinase/integrase	-
M8C01_RS26745	2096321..2096563	-	243	WP_122045118.1	helix-turn-helix domain-containing protein	-
M8C01_RS26750	2097143..2097595	+	453	WP_021018079.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (37-300)

Antitoxin

• Protein of unknown function DUF6088 (7-130)

Sequences

Toxin

Protein

• Length: 314 a.a.
• Molecular weight: 35732.17 Da
• Isoelectric Point: 5.4766

>T246394 WP_122045120.1 NZ_CP097859:c2094854-2093913 [Vibrio owensii]
MNTLKQQFLEVSDALELGNPAIIEKDYWVVALLAELAKVCPEHHQMVFSGGTALAKSNVKILRMSEDVDIKLIPNQAFDE
LSRAKKKAARKACINEIEQALTQSGRFNVETRSVRDEYRYVEFELKYPQQFSQAPCLRPIIKLELIETIPLLDVESRSIQ
SLVAELYQQPQEVSAFDCVSIHATLVEKIISMLRRTMSVKRNTERSDDVALVRHIYDVHCIAKLSMPELDSIDGLFKAVL
AEDIARFGNQHAEFVANPKQELQLGLKELEENAIFRQRFQDFVTPMVFNTEPHDFDTCFASFKRIAASLIEKI

Nucleotide

• Length: 942 bp

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 15153.57 Da
• Isoelectric Point: 10.4983

>AT246394 WP_122045119.1 NZ_CP097859:c2095260-2094856 [Vibrio owensii]
MTAVDRICQKIKRSRRYVFERKDFDGFASYDQIGRALRQLVLQGELMKLGYGLYTKARINSLTGKPMPTNPGGTDALMRE
ILKMKGVDFEMDSLSLQSLSGTSTQIPSSIQYSWDPKQFNRKLVVGSRVLNLPS

Nucleotide

• Length: 405 bp