Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 5548512..5549017 Replicon chromosome
Accession NZ_CP097857
Organism Pseudomonas sp. B111

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag M6E97_RS25685 Protein ID WP_003083773.1
Coordinates 5548512..5548793 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag M6E97_RS25690 Protein ID WP_003083775.1
Coordinates 5548790..5549017 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M6E97_RS25660 (M6E97_25620) 5543763..5545112 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
M6E97_RS25665 (M6E97_25625) 5545161..5545847 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
M6E97_RS25670 (M6E97_25630) 5545948..5546682 + 735 WP_003110658.1 GntR family transcriptional regulator -
M6E97_RS25675 (M6E97_25635) 5546862..5547272 + 411 WP_003110659.1 aegerolysin family protein -
M6E97_RS25680 (M6E97_25640) 5547304..5548212 - 909 WP_003083769.1 LysR family transcriptional regulator -
M6E97_RS25685 (M6E97_25645) 5548512..5548793 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
M6E97_RS25690 (M6E97_25650) 5548790..5549017 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
M6E97_RS25695 (M6E97_25655) 5549193..5549813 - 621 WP_003101226.1 hypothetical protein -
M6E97_RS25700 (M6E97_25660) 5549914..5550414 + 501 WP_003162763.1 LEA type 2 family protein -
M6E97_RS25705 (M6E97_25665) 5550487..5550828 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
M6E97_RS25710 (M6E97_25670) 5550910..5552337 - 1428 WP_003083784.1 GABA permease -
M6E97_RS25715 (M6E97_25675) 5552506..5553999 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T246390 WP_003083773.1 NZ_CP097857:c5548793-5548512 [Pseudomonas sp. B111]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT246390 WP_003083775.1 NZ_CP097857:c5549017-5548790 [Pseudomonas sp. B111]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References