Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1166711..1167328 Replicon chromosome
Accession NC_013956
Organism Pantoea ananatis LMG 20103

Toxin (Protein)


Gene name Hha Uniprot ID D4GLR0
Locus tag PANA_RS05205 Protein ID WP_013024903.1
Coordinates 1166711..1166926 (-) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A8A4KA49
Locus tag PANA_RS05210 Protein ID WP_015700827.1
Coordinates 1166951..1167328 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PANA_RS05180 1162632..1162970 + 339 WP_013024898.1 P-II family nitrogen regulator -
PANA_RS05185 1163004..1164293 + 1290 WP_014606435.1 ammonium transporter AmtB -
PANA_RS05190 1164340..1165203 - 864 WP_013024900.1 acyl-CoA thioesterase II -
PANA_RS05195 1165396..1165953 + 558 WP_013024901.1 YbaY family lipoprotein -
PANA_RS05200 1166002..1166313 - 312 WP_015700828.1 MGMT family protein -
PANA_RS05205 1166711..1166926 - 216 WP_013024903.1 hemolysin expression modulator Hha Toxin
PANA_RS05210 1166951..1167328 - 378 WP_015700827.1 Hha toxicity modulator TomB Antitoxin
PANA_RS05215 1167475..1167828 - 354 WP_013024905.1 hypothetical protein -
PANA_RS05220 1168183..1168851 + 669 WP_014606429.1 ABC transporter ATP-binding protein -
PANA_RS05225 1168848..1169687 + 840 WP_013024907.1 metal ABC transporter permease -
PANA_RS05230 1169700..1170578 + 879 WP_013024908.1 metal ABC transporter substrate-binding protein -
PANA_RS05235 1170638..1170778 - 141 WP_014606428.1 type B 50S ribosomal protein L36 -
PANA_RS05240 1170790..1171044 - 255 WP_014606427.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8552.98 Da        Isoelectric Point: 9.4825

>T24639 WP_013024903.1 NC_013956:c1166926-1166711 [Pantoea ananatis LMG 20103]
MNKTLTKTDYLMRLRRCRSIDTLERVIEKNKYELPDEELAVFYSAADHRLAELTMNKLYDKVPVSVWKFVR

Download         Length: 216 bp

>T24639 NC_013956:c1166926-1166711 [Pantoea ananatis LMG 20103]
ATGAACAAAACCCTAACTAAAACTGATTATTTGATGCGACTGAGGCGCTGTCGTTCTATTGACACGCTGGAACGCGTGAT
TGAAAAAAATAAGTACGAATTACCCGATGAAGAATTAGCAGTATTTTACTCAGCAGCCGATCACCGCCTGGCTGAACTGA
CGATGAACAAGCTCTATGACAAAGTCCCGGTGTCAGTCTGGAAATTTGTACGCTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14722.35 Da        Isoelectric Point: 4.3976

>AT24639 WP_015700827.1 NC_013956:c1167328-1166951 [Pantoea ananatis LMG 20103]
MDEYSPKRHDIAQLKYLCENLFDDSMATLTDSHHGWVNDPTAESNLQLNDLIEHIASFTMNYKIKHVEDEALITQIDEYL
DDTFMLFSNYSVNTQDLQRWQRSAKRLFNVFTEECAFLQQPSHSL

Download         Length: 378 bp

>AT24639 NC_013956:c1167328-1166951 [Pantoea ananatis LMG 20103]
ATGGACGAATACTCACCGAAACGGCATGATATTGCCCAGCTTAAATACTTGTGTGAGAATCTGTTTGACGACAGCATGGC
GACATTAACTGACAGTCATCACGGCTGGGTTAATGACCCCACTGCCGAAAGCAATTTACAGCTAAACGATTTGATTGAGC
ACATCGCCTCTTTCACCATGAATTACAAAATTAAGCACGTTGAAGACGAAGCACTGATTACCCAAATCGATGAATATCTT
GATGATACCTTTATGCTGTTTAGCAACTACAGTGTAAATACTCAGGATCTTCAGCGCTGGCAACGCTCAGCGAAACGTTT
ATTTAATGTGTTTACTGAAGAGTGCGCTTTTCTTCAACAGCCAAGCCATTCATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References