Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2917724..2918945 Replicon chromosome
Accession NZ_CP097857
Organism Pseudomonas sp. B111

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag M6E97_RS13475 Protein ID WP_003110488.1
Coordinates 2918367..2918945 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M6E97_RS13470 Protein ID WP_003117666.1
Coordinates 2917724..2918278 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M6E97_RS13445 (M6E97_13425) 2913296..2913847 + 552 WP_003132721.1 XRE family transcriptional regulator -
M6E97_RS13450 (M6E97_13430) 2913844..2914242 - 399 WP_033990114.1 NADH-quinone oxidoreductase subunit A -
M6E97_RS13455 (M6E97_13435) 2914255..2914578 - 324 WP_003102734.1 multidrug efflux SMR transporter -
M6E97_RS13460 (M6E97_13440) 2914909..2915370 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
M6E97_RS13465 (M6E97_13445) 2915375..2917570 + 2196 WP_023875495.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
M6E97_RS13470 (M6E97_13450) 2917724..2918278 + 555 WP_003117666.1 helix-turn-helix transcriptional regulator Antitoxin
M6E97_RS13475 (M6E97_13455) 2918367..2918945 + 579 WP_003110488.1 HD domain-containing protein Toxin
M6E97_RS13480 (M6E97_13460) 2919055..2920242 - 1188 WP_003139884.1 HlyD family efflux transporter periplasmic adaptor subunit -
M6E97_RS13485 (M6E97_13465) 2920232..2922403 - 2172 WP_003088105.1 type I secretion system permease/ATPase -
M6E97_RS13490 (M6E97_13470) 2922393..2923670 - 1278 WP_003088104.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-66)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T246388 WP_003110488.1 NZ_CP097857:2918367-2918945 [Pseudomonas sp. B111]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.67 Da        Isoelectric Point: 8.5356

>AT246388 WP_003117666.1 NZ_CP097857:2917724-2918278 [Pseudomonas sp. B111]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADKALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References