Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta(toxin) |
| Location | 8714..10365 | Replicon | plasmid pConj |
| Accession | NZ_CP097847 | ||
| Organism | Neisseria gonorrhoeae strain AT159 | ||
Toxin (Protein)
| Gene name | ng_zeta1 | Uniprot ID | D5K9G7 |
| Locus tag | M8779_RS11810 | Protein ID | WP_003701905.1 |
| Coordinates | 9160..10365 (-) | Length | 402 a.a. |
Antitoxin (Protein)
| Gene name | ng_epsilon1 | Uniprot ID | D5K9G8 |
| Locus tag | M8779_RS11805 | Protein ID | WP_003701903.1 |
| Coordinates | 8714..9145 (-) | Length | 144 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M8779_RS11775 (M8779_11770) | 3823..4599 | + | 777 | WP_003701891.1 | P-type conjugative transfer protein TrbJ | - |
| M8779_RS11780 (M8779_11775) | 4813..6441 | + | 1629 | WP_003701894.1 | P-type conjugative transfer protein TrbL | - |
| M8779_RS11785 (M8779_11780) | 6434..7006 | + | 573 | WP_014580059.1 | TrbM/KikA/MpfK family conjugal transfer protein | - |
| M8779_RS11790 (M8779_11785) | 7006..7605 | + | 600 | WP_003701898.1 | TrbN protein | - |
| M8779_RS11795 (M8779_11790) | 7708..7998 | + | 291 | WP_003701899.1 | virulence factor | - |
| M8779_RS11800 (M8779_11795) | 8108..8662 | - | 555 | WP_003701901.1 | recombinase family protein | - |
| M8779_RS11805 (M8779_11800) | 8714..9145 | - | 432 | WP_003701903.1 | hypothetical protein | Antitoxin |
| M8779_RS11810 (M8779_11805) | 9160..10365 | - | 1206 | WP_003701905.1 | toxin | Toxin |
| M8779_RS11815 (M8779_11810) | 10372..10557 | - | 186 | WP_003701907.1 | hypothetical protein | - |
| M8779_RS11820 (M8779_11815) | 10591..11799 | - | 1209 | WP_003701908.1 | zeta toxin family protein | - |
| M8779_RS11825 (M8779_11820) | 11796..12050 | - | 255 | WP_013085578.1 | hypothetical protein | - |
| M8779_RS11830 (M8779_11825) | 12427..12948 | - | 522 | WP_003701911.1 | hypothetical protein | - |
| M8779_RS11835 (M8779_11830) | 13336..13452 | + | 117 | WP_001791010.1 | tetracycline resistance determinant leader peptide | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | tet(M) | - | 1..41997 | 41997 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 402 a.a. Molecular weight: 44675.53 Da Isoelectric Point: 7.7756
>T246385 WP_003701905.1 NZ_CP097847:c10365-9160 [Neisseria gonorrhoeae]
MVKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHN
SAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVA
VSMRAERASDNTYKRFNEYGRGASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQE
QILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGI
YLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSAKKSIS
R
MVKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHN
SAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVA
VSMRAERASDNTYKRFNEYGRGASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQE
QILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGI
YLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSAKKSIS
R
Download Length: 1206 bp
Antitoxin
Download Length: 144 a.a. Molecular weight: 15927.05 Da Isoelectric Point: 4.4211
>AT246385 WP_003701903.1 NZ_CP097847:c9145-8714 [Neisseria gonorrhoeae]
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ
Download Length: 432 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|