Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1026923..1027578 Replicon chromosome
Accession NZ_CP097846
Organism Neisseria gonorrhoeae strain AT159

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag M8779_RS05330 Protein ID WP_003691083.1
Coordinates 1026923..1027342 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag M8779_RS05335 Protein ID WP_003688410.1
Coordinates 1027342..1027578 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8779_RS05310 (M8779_05300) 1022157..1023698 - 1542 WP_172587033.1 MDR family MFS transporter -
M8779_RS05315 (M8779_05305) 1023846..1024625 + 780 WP_003688416.1 (Fe-S)-binding protein -
M8779_RS05320 (M8779_05310) 1024622..1025323 + 702 WP_003688414.1 lactate utilization protein C -
M8779_RS05325 (M8779_05315) 1025320..1026774 + 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
M8779_RS05330 (M8779_05320) 1026923..1027342 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
M8779_RS05335 (M8779_05325) 1027342..1027578 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
M8779_RS05340 (M8779_05330) 1028026..1028604 - 579 WP_003688041.1 IS3 family transposase -
M8779_RS05345 (M8779_05335) 1028609..1028899 - 291 WP_041420764.1 helix-turn-helix domain-containing protein -
M8779_RS05350 (M8779_05340) 1029249..1029635 + 387 Protein_1054 IS110 family transposase -
M8779_RS05355 (M8779_05345) 1030018..1030908 - 891 WP_003688409.1 succinate--CoA ligase subunit alpha -
M8779_RS05360 (M8779_05350) 1030919..1032085 - 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
M8779_RS05365 (M8779_05355) 1032157..1032444 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T246383 WP_003691083.1 NZ_CP097846:c1027342-1026923 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT246383 WP_003688410.1 NZ_CP097846:c1027578-1027342 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References