Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) zeta-pezA/zeta-couple_hipB
Location 805407..806641 Replicon chromosome
Accession NZ_CP097843
Organism Streptococcus oralis strain HP01

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag M9H69_RS04225 Protein ID WP_250316008.1
Coordinates 805883..806641 (+) Length 253 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag M9H69_RS04220 Protein ID WP_000579606.1
Coordinates 805407..805883 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9H69_RS04180 (M9H69_04180) 801662..801946 + 285 WP_250316005.1 DUF5962 family protein -
M9H69_RS04185 (M9H69_04185) 801960..802256 + 297 WP_000998893.1 DUF5966 family protein -
M9H69_RS04190 (M9H69_04190) 802270..802467 - 198 WP_212576400.1 hypothetical protein -
M9H69_RS04195 (M9H69_04195) 802627..803268 + 642 WP_084889489.1 peptidylprolyl isomerase -
M9H69_RS04200 (M9H69_04200) 803278..804363 + 1086 WP_250316006.1 toprim domain-containing protein -
M9H69_RS04205 (M9H69_04205) 804414..804647 + 234 WP_000152421.1 DUF5965 family protein -
M9H69_RS04210 (M9H69_04210) 804644..805027 + 384 WP_250316007.1 DUF5945 family protein -
M9H69_RS04215 (M9H69_04215) 805065..805337 + 273 WP_000495440.1 hypothetical protein -
M9H69_RS04220 (M9H69_04220) 805407..805883 + 477 WP_000579606.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
M9H69_RS04225 (M9H69_04225) 805883..806641 + 759 WP_250316008.1 type II toxin-antitoxin system toxin PezT Toxin
M9H69_RS04230 (M9H69_04230) 806905..807588 + 684 WP_250316009.1 helix-turn-helix transcriptional regulator -
M9H69_RS04235 (M9H69_04235) 807591..809006 + 1416 WP_250316010.1 Y-family DNA polymerase -
M9H69_RS04240 (M9H69_04240) 809006..809368 + 363 WP_250316011.1 hypothetical protein -
M9H69_RS04245 (M9H69_04245) 809358..809648 + 291 WP_001080185.1 DUF5960 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 253 a.a.        Molecular weight: 28738.60 Da        Isoelectric Point: 8.0941

>T246380 WP_250316008.1 NZ_CP097843:805883-806641 [Streptococcus oralis]
MEIQDYTGSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVILDGDSFRSQHPHYSGLQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAATVLHDLLFGEWNQVEKEML
KSGEERLKDLTN

Download         Length: 759 bp

>T246380 NZ_CP097843:805883-806641 [Streptococcus oralis]
ATGGAAATCCAAGATTATACTGGTAGTGAATTCAAACATGCTCTAGCACGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCAATTTTGCTTGGAGGGCAAAGTGGTGCTGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCTTAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTCAGGACTGCAGCAA
GAATATGGCAAAGATAGTGTAGAATACACCAAAGATTTTGCAGGGAAAATGGTAGAGTCTTTAGTAACAGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACGATTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAGTA
GGGGATATGAAGTACAATTAGCCTTGATTGCGACAAAGCCTAAGCTGTCCTATCTGAGCACCCTTATCCGATATGAAGAA
CTATACGCTATCAATCCAAATCAAGCACGTGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGGCAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAACCGTTCTTCATGATTTACTATTTGGAGAATGGAATCAAGTGGAGAAAGAGATGCTT
AAATCTGGAGAAGAAAGATTGAAAGATTTAACTAATTGA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18278.73 Da        Isoelectric Point: 4.4188

>AT246380 WP_000579606.1 NZ_CP097843:805407-805883 [Streptococcus oralis]
MIGKNIKSLRKTHDLTQLEFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVENFDEIERYSGYLDGIERMLEMSEKRMVA

Download         Length: 477 bp

>AT246380 NZ_CP097843:805407-805883 [Streptococcus oralis]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACTCGAATTTGCACGGATTGTAGGTATTTC
ACGAAATAGTCTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACCGAATTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGTATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAAATTTTGATG
AAATTGAGAGGTATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATGTCTGAAAAACGGATGGTAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References