24638

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 946178..947639 Replicon chromosome
Accession NC_013948
Organism Mycoplasma agalactiae

Toxin (Protein)


Gene name abiEi Uniprot ID C5JAE0
Locus tag MAGA_RS04060 Protein ID WP_013022325.1
Coordinates 946178..947032 (-) Length 285 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID C5JAE1
Locus tag MAGA_RS04065 Protein ID WP_013022326.1
Coordinates 947025..947639 (-) Length 205 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAGA_RS04595 942739..942927 - 189 Protein_766 variable surface lipoprotein -
MAGA_RS04600 943742..944182 + 441 Protein_767 variable surface lipoprotein -
MAGA_RS04605 945054..945245 - 192 Protein_768 variable surface lipoprotein -
MAGA_RS04385 945393..946049 - 657 WP_013022158.1 variable surface lipoprotein -
MAGA_RS04060 946178..947032 - 855 WP_013022325.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
MAGA_RS04065 947025..947639 - 615 WP_013022326.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
MAGA_RS04610 947823..948017 + 195 Protein_772 variable surface lipoprotein -
MAGA_RS04615 948642..948761 + 120 Protein_773 variable surface lipoprotein -
MAGA_RS04620 949602..949754 + 153 Protein_774 variable surface lipoprotein -
MAGA_RS04395 950967..951626 + 660 WP_013022329.1 variable surface lipoprotein -
MAGA_RS04645 951761..952240 + 480 Protein_776 variable surface lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-234)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(23-59)


Sequences

Toxin        


Download         Length: 285 a.a.        Molecular weight: 33166.45 Da        Isoelectric Point: 9.0941

>T24638 WP_013022325.1 NC_013948:c947032-946178 [Mycoplasma agalactiae]
MNKNKLISLCHKIADESSANFNVVLIQYFMEGVLRRISKSNERDNFVFKGGFLLSNIMGLDKRSTMDIDLEMIKVQKISA
AKIIEKFNNILKVDEEDGIKYQILKYTDIRKEHRYSGINISLLCQIENIRQVISIDIASGDVITPKEIVYEYKSMFSNQN
FSILAYNIETMLAEKLETIFSFGFFNTRFKDFYDVYVIYAFKSKNIDIDRLENACYNTFKNRNSEFNIQQLIELINKISL
NPLMNERNKYISQLNNQQKINFKTVTDSIMKLLELIKGKEHIK

Download         Length: 855 bp

>T24638 NC_013948:c947032-946178 [Mycoplasma agalactiae]
ATGAATAAGAATAAATTAATAAGTTTGTGTCATAAAATTGCAGATGAAAGCAGCGCAAATTTCAATGTGGTTTTAATTCA
ATATTTTATGGAAGGTGTGCTAAGAAGAATATCTAAAAGCAATGAACGAGATAATTTTGTATTTAAGGGCGGTTTTCTTT
TGTCTAACATTATGGGCTTAGATAAAAGATCCACAATGGATATTGATTTAGAGATGATAAAAGTTCAAAAAATAAGCGCT
GCTAAAATAATAGAAAAATTTAATAACATATTAAAAGTTGATGAAGAAGATGGAATTAAATATCAAATCCTAAAGTATAC
GGACATTAGAAAAGAGCATAGATACAGTGGCATTAACATATCACTGCTATGCCAAATAGAAAATATAAGACAGGTTATTT
CTATAGACATTGCTTCAGGGGATGTTATTACACCCAAAGAAATTGTTTATGAATACAAAAGTATGTTTTCAAATCAGAAT
TTTTCTATTTTAGCTTATAACATTGAAACTATGCTGGCTGAAAAACTTGAAACAATATTTTCTTTTGGCTTTTTTAATAC
AAGGTTTAAAGATTTTTATGACGTCTATGTTATCTATGCTTTTAAAAGCAAAAATATTGATATTGATAGACTTGAAAATG
CTTGTTACAACACATTTAAAAATAGAAATAGTGAATTTAACATACAGCAATTAATAGAGTTAATTAACAAGATTTCTTTA
AATCCGTTGATGAATGAAAGATGAAATAAGTACATAAGTCAGCTAAATAACCAGCAGAAAATAAACTTTAAAACTGTAAC
TGATTCAATAATGAAACTACTTGAACTAATAAAAGGTAAGGAACACATAAAATAA

Antitoxin


Download         Length: 205 a.a.        Molecular weight: 24506.43 Da        Isoelectric Point: 9.6242

>AT24638 WP_013022326.1 NC_013948:c947639-947025 [Mycoplasma agalactiae]
MEQKQLNSKYYKIIYQLLYENDGVITYKQLKEHNIPSIYLTRMIRKGTLIRKTKGIYIINNGHYDEYYFLSKNYNSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKYANVYYCDRDIHSIGLSEAKTIFGNKVRVYDFERTICDFVKLRKKTD
SEIFSKLIGAYIKYEKKDLKKLYEYAYKLGIYKKILEIFELFYE

Download         Length: 615 bp

>AT24638 NC_013948:c947639-947025 [Mycoplasma agalactiae]
ATGGAACAAAAGCAATTGAATTCTAAATATTACAAGATAATTTATCAACTATTATATGAGAATGATGGTGTTATAACATA
TAAACAACTAAAGGAACATAATATTCCTAGTATATATTTAACAAGAATGATAAGAAAAGGCACTCTTATTAGGAAAACCA
AAGGCATTTATATTATTAATAATGGGCATTATGATGAATATTATTTCCTAAGCAAAAACTATAATTCATTGATTTTTTCT
CATTATAGTGCACTATATCTGAACAATATTATTGACATTTTTCCACACCAAATTGATGTTACGGTTTACAGTGGCTATAA
TGCAAAAGGCATTAAAAAGTATGCAAATGTTTACTACTGTGATAGAGATATACATTCAATTGGACTGTCAGAAGCAAAAA
CAATATTTGGCAACAAAGTAAGGGTATATGACTTTGAGAGAACAATATGTGATTTTGTAAAGCTGCGCAAAAAAACAGAT
AGTGAAATTTTTTCTAAGCTTATTGGAGCATATATTAAGTATGAAAAGAAAGATCTAAAAAAATTATATGAATATGCCTA
TAAATTAGGCATATATAAAAAAATATTGGAGATATTTGAATTATTTTATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C5JAE0

Antitoxin

Source ID Structure
AlphaFold DB C5JAE1

References