Detailed information of TA system TA024637

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 5783361..5784022
• Replicon: chromosome
• Accession: NC_013947
• Organism: Stackebrandtia nassauensis DSM 44728

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: D3PVW0
• Locus tag: SNAS_RS26930
• Protein ID: WP_013020652.1
• Coordinates: 5783361..5783786 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: SNAS_RS35435
• Protein ID: WP_013020653.1
• Coordinates: 5783783..5784022 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SNAS_RS26915	5780973..5782322	+	1350	WP_013020649.1	erythromycin esterase family protein	-
SNAS_RS26920	5782412..5782936	+	525	WP_013020650.1	DUF1697 domain-containing protein	-
SNAS_RS26925	5782933..5783331	-	399	WP_013020651.1	hypothetical protein	-
SNAS_RS26930	5783361..5783786	-	426	WP_013020652.1	PIN domain-containing protein	Toxin
SNAS_RS35435	5783783..5784022	-	240	WP_013020653.1	ribbon-helix-helix domain-containing protein	Antitoxin
SNAS_RS26935	5784057..5784404	-	348	WP_013020654.1	histidine triad nucleotide-binding protein	-
SNAS_RS26940	5784401..5785294	-	894	WP_013020655.1	LysR family transcriptional regulator	-
SNAS_RS26945	5785400..5786032	+	633	WP_013020656.1	dihydrofolate reductase family protein	-
SNAS_RS26950	5786038..5786604	+	567	WP_013020657.1	hypothetical protein	-
SNAS_RS26955	5786608..5787759	-	1152	WP_211207254.1	molecular chaperone DnaJ	-
SNAS_RS26960	5787816..5788838	-	1023	WP_013020659.1	heat-inducible transcriptional repressor HrcA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• Predicted DNA-binding protein, ribbon-helix-helix domain (2-39)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15569.73 Da
• Isoelectric Point: 4.2737

>T24637 WP_013020652.1 NC_013947:c5783786-5783361 [Stackebrandtia nassauensis DSM 44728]
VIVIADTSGILVAIDAAHELHDRGRRVFAHAETVLVTPMVLAEVDYLLTSRFGVQTALDFLDEINDGACVVYDVVDGDLR
AARELMAQYFDLAIGLTDAMNVVAADRWHTDRILTLDERHFRTVAPIHPELDAFTLLPVDG

Nucleotide

• Length: 426 bp

>T24637 NC_013947:c5783786-5783361 [Stackebrandtia nassauensis DSM 44728]
GTGATCGTGATCGCCGACACTTCCGGCATCCTCGTCGCCATCGACGCCGCCCACGAACTGCACGATCGAGGTCGGAGAGT
CTTCGCGCACGCCGAGACAGTCCTCGTGACGCCTATGGTGCTTGCGGAGGTCGACTATTTGTTGACCAGTCGATTCGGTG
TTCAAACCGCGCTGGACTTTCTTGACGAGATCAACGACGGCGCGTGCGTTGTCTACGACGTGGTTGATGGAGACCTGCGT
GCCGCGCGTGAGTTGATGGCCCAATACTTTGACCTGGCGATTGGACTGACTGACGCGATGAATGTCGTGGCTGCGGATCG
TTGGCATACCGATCGCATATTGACCCTTGATGAGCGCCATTTTCGAACGGTGGCGCCTATTCACCCGGAACTGGACGCGT
TCACGCTGCTACCCGTCGACGGATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8516.67 Da
• Isoelectric Point: 10.5917

>AT24637 WP_013020653.1 NC_013947:c5784022-5783783 [Stackebrandtia nassauensis DSM 44728]
MKRTTVYLPEADAQLLKQVARRTGKSEAQLIREGVAHVLQAAPTRARGLRMVVNSGDPQWANRVDGELASGFGADGLSQ

Nucleotide

• Length: 240 bp

>AT24637 NC_013947:c5784022-5783783 [Stackebrandtia nassauensis DSM 44728]
ATGAAGCGAACAACGGTGTACCTGCCGGAAGCGGATGCCCAGCTGCTGAAACAGGTGGCACGCCGCACCGGAAAATCAGA
GGCGCAATTGATTCGTGAAGGTGTCGCTCATGTCCTTCAAGCCGCGCCCACTCGTGCACGCGGCTTGCGTATGGTCGTCA
ACAGCGGGGATCCTCAATGGGCGAATCGCGTGGATGGCGAATTGGCAAGTGGATTCGGTGCGGACGGCCTTTCGCAGTGA

Structures

Toxin

• AlphaFold DB: D3PVW0