Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1796620..1797274 Replicon chromosome
Accession NZ_CP097840
Organism Shigella flexneri strain A

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag M9382_RS08715 Protein ID WP_000244767.1
Coordinates 1796867..1797274 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q0T100
Locus tag M9382_RS08710 Protein ID WP_000354044.1
Coordinates 1796620..1796886 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9382_RS08685 (1791791) 1791791..1792533 + 743 Protein_1687 SDR family oxidoreductase -
M9382_RS08690 (1792590) 1792590..1794023 - 1434 WP_005076748.1 6-phospho-beta-glucosidase BglA -
M9382_RS08695 (1794068) 1794068..1794378 + 311 Protein_1689 N(4)-acetylcytidine aminohydrolase -
M9382_RS08700 (1794542) 1794542..1795201 + 660 WP_000250274.1 hemolysin III family protein -
M9382_RS08705 (1795397) 1795397..1796377 - 981 WP_000886065.1 tRNA-modifying protein YgfZ -
M9382_RS08710 (1796620) 1796620..1796886 + 267 WP_000354044.1 FAD assembly factor SdhE Antitoxin
M9382_RS08715 (1796867) 1796867..1797274 + 408 WP_000244767.1 protein YgfX Toxin
M9382_RS08720 (1797314) 1797314..1797835 - 522 WP_001055867.1 flavodoxin FldB -
M9382_RS08725 (1797947) 1797947..1798843 + 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
M9382_RS08730 (1798868) 1798868..1799578 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M9382_RS08735 (1799584) 1799584..1801317 + 1734 WP_000813187.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T246363 WP_000244767.1 NZ_CP097840:1796867-1797274 [Shigella flexneri]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT246363 WP_000354044.1 NZ_CP097840:1796620-1796886 [Shigella flexneri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TIU2

References