Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4057759..4058390 Replicon chromosome
Accession NZ_CP097837
Organism Shigella flexneri strain B

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag M9380_RS20605 Protein ID WP_025760846.1
Coordinates 4058115..4058390 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag M9380_RS20600 Protein ID WP_000593555.1
Coordinates 4057759..4058118 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9380_RS20575 (4053891) 4053891..4054835 + 945 WP_000947076.1 nickel ABC transporter permease subunit NikB -
M9380_RS20580 (4054832) 4054832..4055665 + 834 WP_001008974.1 nickel ABC transporter permease subunit NikC -
M9380_RS20585 (4055665) 4055665..4056429 + 765 WP_001136248.1 nickel import ATP-binding protein NikD -
M9380_RS20590 (4056426) 4056426..4057232 + 807 WP_000173660.1 nickel import ATP-binding protein NikE -
M9380_RS20595 (4057238) 4057238..4057639 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
M9380_RS20600 (4057759) 4057759..4058118 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M9380_RS20605 (4058115) 4058115..4058390 - 276 WP_025760846.1 type II toxin-antitoxin system HicA family toxin Toxin
M9380_RS20610 (4058449) 4058449..4059573 - 1125 WP_001216257.1 ABC transporter permease -
M9380_RS20615 (4059573) 4059573..4062308 - 2736 WP_000149172.1 ribosome-associated ATPase/putative transporter RbbA -
M9380_RS20620 (4062305) 4062305..4063372 - 1068 WP_000361470.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-81)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10145.95 Da        Isoelectric Point: 10.6469

>T246353 WP_025760846.1 NZ_CP097837:c4058390-4058115 [Shigella flexneri]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKKGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
CDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT246353 WP_000593555.1 NZ_CP097837:c4058118-4057759 [Shigella flexneri]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References