Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3496552..3497206 Replicon chromosome
Accession NZ_CP097837
Organism Shigella flexneri strain B

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag M9380_RS17715 Protein ID WP_000244767.1
Coordinates 3496552..3496959 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q0T100
Locus tag M9380_RS17720 Protein ID WP_000354044.1
Coordinates 3496940..3497206 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9380_RS17695 (3492509) 3492509..3494242 - 1734 WP_000813187.1 single-stranded-DNA-specific exonuclease RecJ -
M9380_RS17700 (3494248) 3494248..3494958 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M9380_RS17705 (3494983) 3494983..3495879 - 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
M9380_RS17710 (3495991) 3495991..3496512 + 522 WP_001055867.1 flavodoxin FldB -
M9380_RS17715 (3496552) 3496552..3496959 - 408 WP_000244767.1 protein YgfX Toxin
M9380_RS17720 (3496940) 3496940..3497206 - 267 WP_000354044.1 FAD assembly factor SdhE Antitoxin
M9380_RS17725 (3497449) 3497449..3498429 + 981 WP_000886065.1 tRNA-modifying protein YgfZ -
M9380_RS17730 (3498625) 3498625..3499284 - 660 WP_000250274.1 hemolysin III family protein -
M9380_RS17735 (3499448) 3499448..3499758 - 311 Protein_3443 N(4)-acetylcytidine aminohydrolase -
M9380_RS17740 (3499803) 3499803..3501236 + 1434 WP_005076748.1 6-phospho-beta-glucosidase BglA -
M9380_RS17745 (3501293) 3501293..3502035 - 743 Protein_3445 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T246351 WP_000244767.1 NZ_CP097837:c3496959-3496552 [Shigella flexneri]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT246351 WP_000354044.1 NZ_CP097837:c3497206-3496940 [Shigella flexneri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TIU2

References