Detailed information of TA system TA024634

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 360320..360785
• Replicon: chromosome
• Accession: NC_013946
• Organism: Meiothermus ruber DSM 1279

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: D3PM46
• Locus tag: MRUB_RS01915
• Protein ID: WP_013012676.1
• Coordinates: 360516..360785 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: D3PM45
• Locus tag: MRUB_RS01910
• Protein ID: WP_013012675.1
• Coordinates: 360320..360532 (+)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MRUB_RS01880	355818..356090	-	273	WP_013012669.1	hypothetical protein	-
MRUB_RS01885	356137..357036	-	900	WP_013012670.1	complex I NDUFA9 subunit family protein	-
MRUB_RS01890	357044..357634	-	591	WP_013012671.1	cyclic nucleotide-binding domain-containing protein	-
MRUB_RS01895	357705..358586	-	882	WP_013012672.1	MerR family transcriptional regulator	-
MRUB_RS01900	358708..359385	+	678	WP_013012673.1	class I SAM-dependent methyltransferase	-
MRUB_RS01905	359427..360254	+	828	WP_015586313.1	phytoene/squalene synthase family protein	-
MRUB_RS01910	360320..360532	+	213	WP_013012675.1	TraY domain-containing protein	Antitoxin
MRUB_RS01915	360516..360785	+	270	WP_013012676.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MRUB_RS01920	360827..362359	+	1533	WP_013012677.1	NAD(P)/FAD-dependent oxidoreductase	-
MRUB_RS01925	362480..363673	+	1194	WP_013012678.1	NAD(P)-binding protein	-
MRUB_RS01930	363805..364839	+	1035	WP_013012679.1	carotenoid biosynthesis protein	-
MRUB_RS01935	364836..365525	+	690	WP_013012680.1	1-acyl-sn-glycerol-3-phosphate acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-85)

Antitoxin

• Relaxosome protein TraY (4-45)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10589.25 Da
• Isoelectric Point: 10.2952

>T24634 WP_013012676.1 NC_013946:360516-360785 [Meiothermus ruber DSM 1279]
MGYRIEFDPRAEGELAKLDREVARRIVRFLRERVASLDDPRSIGEALHGPELGRFWKYRVGDYRLICHIQDQRVTVLVLR
IGHRQVVYR

Nucleotide

• Length: 270 bp

>T24634 NC_013946:360516-360785 [Meiothermus ruber DSM 1279]
TTGGGCTACAGGATTGAGTTCGACCCACGGGCCGAGGGAGAGCTGGCGAAACTGGATCGTGAGGTGGCGCGTCGCATCGT
ACGGTTTTTGCGCGAGCGGGTGGCCTCGTTGGATGATCCGCGTAGCATTGGGGAGGCCTTGCACGGGCCGGAGCTGGGCC
GGTTTTGGAAGTACCGGGTAGGGGATTATCGCCTGATCTGCCATATCCAGGATCAGAGGGTCACTGTGCTGGTCTTGCGG
ATTGGGCATCGGCAGGTTGTCTACCGCTGA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 8238.41 Da
• Isoelectric Point: 4.4929

>AT24634 WP_013012675.1 NC_013946:360320-360532 [Meiothermus ruber DSM 1279]
MLAIRLPKEIEERLEALAQKTGRSKSYYVRQAILEHLDDLEDYYLALERLEQNLPGIPLDEVERRLGLQD

Nucleotide

• Length: 213 bp

>AT24634 NC_013946:360320-360532 [Meiothermus ruber DSM 1279]
ATGCTGGCCATTCGGCTGCCCAAGGAGATAGAGGAACGCCTCGAGGCGCTTGCCCAGAAAACCGGGCGCAGCAAGAGCTA
TTACGTGCGCCAGGCCATCCTCGAGCACCTCGATGACCTCGAGGACTACTACCTGGCCCTAGAACGGCTCGAGCAGAACC
TGCCCGGCATCCCCCTAGACGAAGTGGAGCGCCGCCTTGGGCTACAGGATTGA

Structures

Toxin

• AlphaFold DB: D3PM46

Antitoxin

• AlphaFold DB: D3PM45