Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 213143..213768 Replicon plasmid unnamed2
Accession NZ_CP097836
Organism Shigella flexneri strain C

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M9379_RS24455 Protein ID WP_000911087.1
Coordinates 213370..213768 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q7BEJ0
Locus tag M9379_RS24450 Protein ID WP_000450531.1
Coordinates 213143..213370 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9379_RS24450 (M9379_24450) 213143..213370 + 228 WP_000450531.1 toxin-antitoxin system antitoxin VapB Antitoxin
M9379_RS24455 (M9379_24455) 213370..213768 + 399 WP_000911087.1 tRNA(fMet)-specific endonuclease VapC Toxin
M9379_RS24460 (M9379_24460) 213777..213956 - 180 Protein_255 hypothetical protein -
M9379_RS24465 (M9379_24465) 214001..215157 + 1157 WP_258249661.1 IS3 family transposase -
M9379_RS24470 (M9379_24470) 215168..216054 + 887 Protein_257 IS630 family transposase -
M9379_RS24475 (M9379_24475) 216208..217152 - 945 WP_004996485.1 lauroyl-Kdo(2)-lipid IV(A) myristoyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - ospG / ipaH9.8 / ospI / papC / icsA/virG / virA / spa40 / spa29 / spa9 / spa24 / spa33 / spa32 / spa13 / spa47 / spa15 / mxiA / mxiC / mxiD / mxiE / mxiM / mxiL / mxiN / mxiK / mxiJ / mxiI / mxiH / mxiG / ipgF / ipgE / ipgD / icsB / ipgA / ipgB1 / ipgC / ipaB / ipaC / ipaD / ipaA / ipaJ / ospC3 / ospC1 / ospD3/senA / ipaH4.5 / ipaH7.8 / ospC2 / ipaH2.5 / ospE2 / ipgB2 / ospD1 / ospF / ospD2 / ospB / icsP/sopA / nleE / ospE1 / ipaH1.4 1..217682 217682


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14799.04 Da        Isoelectric Point: 8.5232

>T246338 WP_000911087.1 NZ_CP097836:213370-213768 [Shigella flexneri]
MLKFILDTNICIFTIKNKPASVRERFNLNQGKMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRTEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8565.62 Da        Isoelectric Point: 4.7513

>AT246338 WP_000450531.1 NZ_CP097836:213143-213370 [Shigella flexneri]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHSVSTDFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3TND
AlphaFold DB Q7BEJ0

References