Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4270379..4271033 Replicon chromosome
Accession NZ_CP097834
Organism Shigella flexneri strain C

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag M9379_RS21570 Protein ID WP_000244767.1
Coordinates 4270626..4271033 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q0T100
Locus tag M9379_RS21565 Protein ID WP_000354044.1
Coordinates 4270379..4270645 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9379_RS21540 (4265550) 4265550..4266292 + 743 Protein_4193 SDR family oxidoreductase -
M9379_RS21545 (4266349) 4266349..4267782 - 1434 WP_005076748.1 6-phospho-beta-glucosidase BglA -
M9379_RS21550 (4267827) 4267827..4268137 + 311 Protein_4195 N(4)-acetylcytidine aminohydrolase -
M9379_RS21555 (4268301) 4268301..4268960 + 660 WP_000250274.1 hemolysin III family protein -
M9379_RS21560 (4269156) 4269156..4270136 - 981 WP_000886065.1 tRNA-modifying protein YgfZ -
M9379_RS21565 (4270379) 4270379..4270645 + 267 WP_000354044.1 FAD assembly factor SdhE Antitoxin
M9379_RS21570 (4270626) 4270626..4271033 + 408 WP_000244767.1 protein YgfX Toxin
M9379_RS21575 (4271073) 4271073..4271594 - 522 WP_001055867.1 flavodoxin FldB -
M9379_RS21580 (4271706) 4271706..4272602 + 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
M9379_RS21585 (4272627) 4272627..4273337 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M9379_RS21590 (4273343) 4273343..4275076 + 1734 WP_000813187.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T246333 WP_000244767.1 NZ_CP097834:4270626-4271033 [Shigella flexneri]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT246333 WP_000354044.1 NZ_CP097834:4270379-4270645 [Shigella flexneri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TIU2

References