Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 194743..195389 Replicon chromosome
Accession NC_013946
Organism Meiothermus ruber DSM 1279

Toxin (Protein)


Gene name vapC Uniprot ID D3PLA5
Locus tag MRUB_RS01110 Protein ID WP_013012520.1
Coordinates 195009..195389 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D3PLA4
Locus tag MRUB_RS01105 Protein ID WP_013012519.1
Coordinates 194743..195009 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRUB_RS01085 191543..192025 + 483 WP_013012515.1 type III-A CRISPR-associated protein Csm2 -
MRUB_RS01090 192026..192700 + 675 WP_013012516.1 type III-A CRISPR-associated RAMP protein Csm3 -
MRUB_RS01095 192697..193584 + 888 WP_013012517.1 CRISPR-associated protein Csm4 -
MRUB_RS01100 193581..194711 + 1131 WP_013012518.1 type III-A CRISPR-associated RAMP protein Csm5 -
MRUB_RS01105 194743..195009 + 267 WP_013012519.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MRUB_RS01110 195009..195389 + 381 WP_013012520.1 type II toxin-antitoxin system VapC family toxin Toxin
MRUB_RS01115 195386..196174 + 789 WP_013012521.1 CRISPR-associated endoribonuclease Cas6 -
MRUB_RS01120 196128..197594 + 1467 WP_013012522.1 TIGR02710 family CRISPR-associated protein -
MRUB_RS01125 197591..198562 + 972 WP_013012523.1 CRISPR-associated endonuclease Cas1 -
MRUB_RS15970 198677..198841 + 165 WP_013012524.1 CRISPR-associated endonuclease Cas2 -
MRUB_RS01135 199420..199626 + 207 WP_015586271.1 hypothetical protein -
MRUB_RS01140 199623..200042 + 420 Protein_227 putative toxin-antitoxin system toxin component, PIN family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-123)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13670.81 Da        Isoelectric Point: 5.1221

>T24633 WP_013012520.1 NC_013946:195009-195389 [Meiothermus ruber DSM 1279]
MVLDSSVLVQLIFAEPGHRETLEHILEAEVRVVGAPTLVEVGMVLTSRLGPDNLYLLDELLMRLEARVVPFEASHAHQAL
SAFRRCGKGRHPAALNFGDCLSYAVAKVAGMPLAYVGDDFAQTDLA

Download         Length: 381 bp

>T24633 NC_013946:195009-195389 [Meiothermus ruber DSM 1279]
ATGGTGCTGGACAGTTCGGTTCTGGTACAGCTTATTTTTGCCGAGCCAGGGCATCGGGAGACGCTCGAGCACATTCTTGA
GGCCGAGGTGCGCGTGGTGGGGGCACCCACGCTGGTCGAGGTGGGTATGGTGTTGACCAGTCGGTTGGGGCCGGACAACC
TGTACCTGCTGGACGAACTTCTGATGCGCCTCGAGGCCCGGGTGGTTCCTTTCGAGGCAAGCCATGCGCACCAAGCCCTC
TCGGCCTTCCGCCGCTGCGGCAAGGGCCGCCACCCTGCGGCCCTCAACTTTGGCGACTGCCTGAGCTACGCGGTGGCTAA
GGTGGCGGGGATGCCCCTGGCCTACGTAGGCGACGACTTCGCCCAGACCGACCTGGCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9962.49 Da        Isoelectric Point: 5.2827

>AT24633 WP_013012519.1 NC_013946:194743-195009 [Meiothermus ruber DSM 1279]
MALTVKNPEVERLAEEVARLTGETKTEAIRKALLERKARLLYPQRPSKESVLEFLEREVWAKLPPESLGKAPTKAEQEEI
LGFGPEGY

Download         Length: 267 bp

>AT24633 NC_013946:194743-195009 [Meiothermus ruber DSM 1279]
ATGGCCCTGACCGTCAAAAACCCCGAAGTCGAGCGCCTGGCCGAAGAAGTGGCCCGTCTGACCGGCGAGACCAAAACCGA
GGCCATCCGCAAGGCCCTTTTGGAACGCAAGGCCCGGCTTTTGTACCCGCAGCGCCCCAGCAAGGAAAGCGTGCTGGAAT
TTCTAGAGCGCGAGGTCTGGGCCAAACTGCCGCCCGAAAGCTTAGGTAAAGCCCCTACCAAGGCCGAACAAGAGGAAATT
CTGGGCTTTGGCCCGGAGGGCTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A399E7P1

Antitoxin

Source ID Structure
AlphaFold DB A0A399E581

References