Detailed information of TA system TA024632

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2814501..2816064
• Replicon: chromosome
• Accession: NC_013943
• Organism: Denitrovibrio acetiphilus DSM 12809

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: D4H551
• Locus tag: DACET_RS13370
• Protein ID: WP_013011901.1
• Coordinates: 2814742..2816064 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: DACET_RS13365
• Protein ID: WP_013011900.1
• Coordinates: 2814501..2814740 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DACET_RS13335	2809551..2810378	-	828	WP_013011895.1	hypothetical protein	-
DACET_RS13340	2810446..2811726	-	1281	WP_013011896.1	hypothetical protein	-
DACET_RS13355	2813094..2814002	+	909	WP_013011898.1	WYL domain-containing transcriptional regulator	-
DACET_RS13360	2814062..2814370	+	309	WP_013011899.1	hypothetical protein	-
DACET_RS13365	2814501..2814740	+	240	WP_013011900.1	helix-turn-helix domain-containing protein	Antitoxin
DACET_RS13370	2814742..2816064	+	1323	WP_013011901.1	type II toxin-antitoxin system HipA family toxin	Toxin
DACET_RS16050	2816074..2816175	-	102	Protein_2654	SEC-C domain-containing protein	-
DACET_RS16055	2816855..2817025	-	171	WP_211204127.1	virulence RhuM family protein	-
DACET_RS13380	2817130..2818167	-	1038	WP_013011903.1	virulence RhuM family protein	-
DACET_RS13385	2818190..2819347	-	1158	WP_013011904.1	Fic family protein	-
DACET_RS13390	2819791..2820123	+	333	WP_013011905.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2811993..2846336	34343

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (10-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-66)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49757.01 Da
• Isoelectric Point: 5.9836

>T24632 WP_013011901.1 NC_013943:2814742-2816064 [Denitrovibrio acetiphilus DSM 12809]
MGRKKTSATLKILMNGMPVGTLERSSSNMLELIYDDQWLESDIRRPISLSLSLFSKKHRGDAVQYFFDNLLPDNQQILDR
IQARYKIGKSNAFDILAEIGRDCIGAIQLTPAEIVGDIHQITSKPQSEADIADTLKNYRLKPLGMGEDEDFRISLAGAQE
KTAFLLLEDRWHLPTGSTPTTHIFKQPIGKIEANNIDLSESVENEWLCHLILKEFGLPVANMAVHTFEDTKALVVERFDR
QWASDGSWIMRLPQEDFCQASGTSPALKYESDGGPGIKDIMALLQGSSKADNDRYTFMKSVFLFWVLGATDGHAKNFSIF
LEPEGRYRLTPLYDILSVYPIMAKKQIHPSKVKMAMSVVGTKKNYLWERIHVDNWIRTADACNFSTTAMREIIEDVLGNM
DSVIEKVQTQLPSDFPAHISEPIFHYMQEIKKKCVSDLAS

Nucleotide

• Length: 1323 bp

>T24632 NC_013943:2814742-2816064 [Denitrovibrio acetiphilus DSM 12809]
ATGGGGCGTAAAAAGACATCTGCAACTTTAAAAATCCTCATGAACGGAATGCCCGTAGGCACTCTTGAACGTAGCTCATC
CAATATGCTAGAGCTTATATACGATGACCAGTGGCTAGAGTCCGACATACGCAGACCGATATCACTATCGCTCTCCTTGT
TCAGCAAGAAACACAGAGGAGACGCAGTACAGTATTTCTTTGACAACCTGCTCCCTGATAATCAACAGATACTAGACAGG
ATACAAGCACGCTATAAAATAGGTAAATCTAATGCTTTTGACATCTTAGCCGAGATAGGACGTGACTGCATCGGAGCTAT
CCAATTGACACCAGCCGAGATCGTTGGAGATATCCACCAGATAACGTCAAAACCACAAAGTGAAGCAGACATAGCCGACA
CTCTGAAAAACTACAGACTCAAGCCCCTTGGCATGGGAGAGGATGAAGATTTCAGAATATCCCTAGCGGGCGCACAGGAA
AAAACAGCCTTCCTCCTGCTTGAAGATAGATGGCACCTGCCGACAGGTTCAACACCAACGACACACATATTTAAGCAGCC
AATTGGCAAGATAGAAGCGAATAACATCGACCTTTCGGAAAGCGTTGAAAATGAATGGCTATGCCACCTTATTCTGAAAG
AGTTCGGTTTGCCTGTGGCGAACATGGCAGTGCATACATTTGAAGATACCAAGGCATTAGTTGTGGAGCGTTTCGACAGG
CAGTGGGCATCAGATGGTTCATGGATCATGAGACTGCCTCAGGAGGACTTTTGTCAGGCTAGCGGTACATCTCCTGCTTT
AAAGTACGAATCCGACGGAGGGCCAGGAATAAAGGATATAATGGCACTGCTCCAAGGTTCATCAAAAGCGGATAATGACA
GGTATACATTCATGAAATCCGTCTTTCTCTTCTGGGTGTTAGGCGCAACAGATGGTCATGCGAAGAATTTCAGCATCTTC
CTTGAGCCCGAGGGGCGCTATCGACTCACTCCACTTTACGATATACTCTCCGTCTACCCCATTATGGCAAAGAAGCAGAT
CCATCCGAGCAAAGTAAAAATGGCGATGTCAGTAGTAGGCACAAAGAAGAATTACCTTTGGGAACGAATACATGTTGATA
ACTGGATACGCACAGCTGATGCATGTAACTTTTCAACAACAGCCATGCGAGAGATAATAGAAGACGTTTTAGGAAACATG
GATAGTGTCATTGAAAAAGTACAAACACAACTTCCTAGTGATTTCCCTGCTCATATCTCTGAACCAATCTTTCATTACAT
GCAGGAAATCAAAAAGAAGTGCGTAAGTGACTTAGCTTCTTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8680.01 Da
• Isoelectric Point: 10.0963

>AT24632 WP_013011900.1 NC_013943:2814501-2814740 [Denitrovibrio acetiphilus DSM 12809]
MNQVVSSPSILGQAIKAARLEAKLTQSQLAEKTGLRQGTISDIENGTQRAKLDTLFIILSALNLDMHLQPKSTNKMSEW

Nucleotide

• Length: 240 bp

>AT24632 NC_013943:2814501-2814740 [Denitrovibrio acetiphilus DSM 12809]
ATGAATCAGGTCGTCAGTTCACCATCAATATTAGGGCAAGCTATTAAAGCAGCAAGACTTGAAGCCAAACTTACACAAAG
TCAACTTGCTGAAAAAACTGGTCTACGACAAGGGACAATATCTGACATCGAAAACGGAACTCAAAGAGCCAAGCTGGATA
CTCTATTCATAATACTGTCAGCCTTAAACTTAGATATGCACCTGCAACCAAAGTCCACCAATAAAATGAGCGAGTGGTAG

Structures

Toxin

• AlphaFold DB: D4H551