Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1797442..1798096 Replicon chromosome
Accession NZ_CP097831
Organism Shigella flexneri strain D

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag M9381_RS08735 Protein ID WP_000244767.1
Coordinates 1797689..1798096 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q0T100
Locus tag M9381_RS08730 Protein ID WP_000354044.1
Coordinates 1797442..1797708 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9381_RS08705 (1792613) 1792613..1793355 + 743 Protein_1691 SDR family oxidoreductase -
M9381_RS08710 (1793412) 1793412..1794845 - 1434 WP_005076748.1 6-phospho-beta-glucosidase BglA -
M9381_RS08715 (1794890) 1794890..1795200 + 311 Protein_1693 N(4)-acetylcytidine aminohydrolase -
M9381_RS08720 (1795364) 1795364..1796023 + 660 WP_000250274.1 hemolysin III family protein -
M9381_RS08725 (1796219) 1796219..1797199 - 981 WP_000886065.1 tRNA-modifying protein YgfZ -
M9381_RS08730 (1797442) 1797442..1797708 + 267 WP_000354044.1 FAD assembly factor SdhE Antitoxin
M9381_RS08735 (1797689) 1797689..1798096 + 408 WP_000244767.1 protein YgfX Toxin
M9381_RS08740 (1798136) 1798136..1798657 - 522 WP_001055867.1 flavodoxin FldB -
M9381_RS08745 (1798769) 1798769..1799665 + 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
M9381_RS08750 (1799690) 1799690..1800400 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M9381_RS08755 (1800406) 1800406..1802139 + 1734 WP_000813187.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T246302 WP_000244767.1 NZ_CP097831:1797689-1798096 [Shigella flexneri]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT246302 WP_000354044.1 NZ_CP097831:1797442-1797708 [Shigella flexneri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TIU2

References