Detailed information of TA system TA024630

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 555735..556366
• Replicon: chromosome
• Accession: NC_013943
• Organism: Denitrovibrio acetiphilus DSM 12809

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: D4H427
• Locus tag: DACET_RS02720
• Protein ID: WP_013009882.1
• Coordinates: 555735..556136 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: D4H428
• Locus tag: DACET_RS02725
• Protein ID: WP_013009883.1
• Coordinates: 556139..556366 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DACET_RS02690	551022..551492	+	471	WP_013009877.1	mobile mystery protein A	-
DACET_RS02695	551556..552338	-	783	WP_013009878.1	hypothetical protein	-
DACET_RS02705	553783..554811	+	1029	WP_013009879.1	hypothetical protein	-
DACET_RS02710	554808..555233	+	426	WP_013009880.1	hypothetical protein	-
DACET_RS02715	555226..555738	-	513	WP_013009881.1	hypothetical protein	-
DACET_RS02720	555735..556136	-	402	WP_013009882.1	type II toxin-antitoxin system VapC family toxin	Toxin
DACET_RS02725	556139..556366	-	228	WP_013009883.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
DACET_RS02730	556675..557901	-	1227	WP_013009884.1	type II toxin-antitoxin system HipA family toxin	-
DACET_RS02735	557898..558218	-	321	WP_211204116.1	helix-turn-helix domain-containing protein	-
DACET_RS02740	558413..559369	+	957	WP_013009886.1	ParM/StbA family protein	-
DACET_RS02745	559438..559674	+	237	WP_013009887.1	hypothetical protein	-
DACET_RS02750	559674..559883	+	210	WP_013009888.1	helix-turn-helix transcriptional regulator	-
DACET_RS02755	559933..560877	+	945	WP_013009889.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	550061..690632	140571

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

• SpoVT-AbrB domain (7-48)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14958.25 Da
• Isoelectric Point: 4.9211

>T24630 WP_013009882.1 NC_013943:c556136-555735 [Denitrovibrio acetiphilus DSM 12809]
MYMLDTNICIYIIKRRPAEIIEKFKTFNISELCISSITAAELHYGVNKSQRVEQNSDALAMFLSPLEILPFDDAAAYEYG
IIRAELEKNGNTIGSMDLPIAAHAKAMNAIIVTNNEREFSRVSGIKVENWVTL

Nucleotide

• Length: 402 bp

>T24630 NC_013943:c556136-555735 [Denitrovibrio acetiphilus DSM 12809]
ATGTATATGCTGGATACCAATATCTGTATTTATATTATAAAGCGCAGACCTGCGGAGATCATCGAGAAATTCAAAACTTT
CAATATTTCTGAGCTGTGTATCTCAAGCATCACAGCAGCGGAATTACATTACGGTGTAAACAAAAGCCAGCGTGTGGAGC
AAAACAGCGACGCTCTGGCGATGTTTCTATCACCTCTGGAGATATTGCCATTTGACGATGCTGCGGCTTATGAATACGGC
ATCATCCGTGCAGAGCTTGAGAAGAACGGCAATACCATAGGCTCAATGGATCTCCCGATAGCGGCACACGCCAAAGCCAT
GAACGCAATCATAGTCACCAATAACGAACGTGAATTCTCCCGTGTATCAGGTATCAAGGTCGAGAATTGGGTGACGTTAT
GA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8884.00 Da
• Isoelectric Point: 4.7265

>AT24630 WP_013009883.1 NC_013943:c556366-556139 [Denitrovibrio acetiphilus DSM 12809]
MDKARVFKSGNSQAVRLPKEYQLNTNEVYIRKVGNMIILLPKADIWSNFEKSLDMFDDSFMSDRQQPDYDDRESF

Nucleotide

• Length: 228 bp

>AT24630 NC_013943:c556366-556139 [Denitrovibrio acetiphilus DSM 12809]
ATGGATAAGGCAAGAGTCTTTAAAAGTGGAAACAGCCAAGCTGTGAGGCTTCCAAAAGAATACCAGTTAAATACGAATGA
GGTCTATATCCGTAAGGTAGGCAACATGATTATCCTGCTGCCGAAGGCAGACATCTGGTCGAACTTTGAAAAAAGTCTTG
ATATGTTTGATGATTCCTTTATGTCTGACAGGCAACAGCCTGACTATGATGACAGGGAGAGCTTCTAG

Structures

Toxin

• AlphaFold DB: D4H427

Antitoxin

• AlphaFold DB: D4H428