Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1074738..1075392 Replicon chromosome
Accession NZ_CP097828
Organism Shigella flexneri strain E

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag M9383_RS05415 Protein ID WP_000244767.1
Coordinates 1074738..1075145 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q0T100
Locus tag M9383_RS05420 Protein ID WP_000354044.1
Coordinates 1075126..1075392 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9383_RS05395 (1070695) 1070695..1072428 - 1734 WP_000813187.1 single-stranded-DNA-specific exonuclease RecJ -
M9383_RS05400 (1072434) 1072434..1073144 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M9383_RS05405 (1073169) 1073169..1074065 - 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
M9383_RS05410 (1074177) 1074177..1074698 + 522 WP_001055867.1 flavodoxin FldB -
M9383_RS05415 (1074738) 1074738..1075145 - 408 WP_000244767.1 protein YgfX Toxin
M9383_RS05420 (1075126) 1075126..1075392 - 267 WP_000354044.1 FAD assembly factor SdhE Antitoxin
M9383_RS05425 (1075635) 1075635..1076615 + 981 WP_000886065.1 tRNA-modifying protein YgfZ -
M9383_RS05430 (1076811) 1076811..1077470 - 660 WP_000250274.1 hemolysin III family protein -
M9383_RS05435 (1077634) 1077634..1077944 - 311 Protein_1049 N(4)-acetylcytidine aminohydrolase -
M9383_RS05440 (1077989) 1077989..1079422 + 1434 WP_005076748.1 6-phospho-beta-glucosidase BglA -
M9383_RS05445 (1079479) 1079479..1080221 - 743 Protein_1051 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T246278 WP_000244767.1 NZ_CP097828:c1075145-1074738 [Shigella flexneri]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT246278 WP_000354044.1 NZ_CP097828:c1075392-1075126 [Shigella flexneri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TIU2

References