Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 5027828..5029509 | Replicon | chromosome |
| Accession | NZ_CP097808 | ||
| Organism | Klebsiella variicola strain 17YN56 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | - |
| Locus tag | M9O80_RS24355 | Protein ID | WP_022065798.1 |
| Coordinates | 5027828..5028745 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A0A0B7GCX3 |
| Locus tag | M9O80_RS24360 | Protein ID | WP_008807257.1 |
| Coordinates | 5028751..5029509 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M9O80_RS24335 (M9O80_24335) | 5023134..5024654 | + | 1521 | WP_008807253.1 | sugar ABC transporter ATP-binding protein | - |
| M9O80_RS24340 (M9O80_24340) | 5024651..5025649 | + | 999 | WP_023296904.1 | ribose ABC transporter permease | - |
| M9O80_RS24345 (M9O80_24345) | 5025680..5026621 | + | 942 | WP_012543155.1 | ABC transporter substrate-binding protein | - |
| M9O80_RS24350 (M9O80_24350) | 5026696..5027703 | + | 1008 | WP_023323480.1 | carbohydrate kinase family protein | - |
| M9O80_RS24355 (M9O80_24355) | 5027828..5028745 | - | 918 | WP_022065798.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| M9O80_RS24360 (M9O80_24360) | 5028751..5029509 | - | 759 | WP_008807257.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| M9O80_RS24365 (M9O80_24365) | 5029594..5030322 | - | 729 | WP_008807258.1 | response regulator transcription factor | - |
| M9O80_RS24370 (M9O80_24370) | 5030595..5032742 | + | 2148 | WP_077598908.1 | formate dehydrogenase subunit alpha | - |
| M9O80_RS24375 (M9O80_24375) | 5033008..5033694 | + | 687 | WP_016160120.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34751.14 Da Isoelectric Point: 5.4707
>T246274 WP_022065798.1 NZ_CP097808:c5028745-5027828 [Klebsiella variicola]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRTIALPHIRDALARIAANLQQQ
AGMNAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRTIALPHIRDALARIAANLQQQ
AGMNAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
Antitoxin
Download Length: 253 a.a. Molecular weight: 28653.01 Da Isoelectric Point: 10.1988
>AT246274 WP_008807257.1 NZ_CP097808:c5029509-5028751 [Klebsiella variicola]
MPSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE
MPSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|