Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4730857..4731433 Replicon chromosome
Accession NZ_CP097808
Organism Klebsiella variicola strain 17YN56

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag M9O80_RS22970 Protein ID WP_012542979.1
Coordinates 4731146..4731433 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag M9O80_RS22965 Protein ID WP_022065028.1
Coordinates 4730857..4731159 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O80_RS22940 (M9O80_22940) 4726265..4727329 - 1065 WP_008807596.1 DUF2955 domain-containing protein -
M9O80_RS22945 (M9O80_22945) 4727319..4728386 - 1068 WP_022065029.1 HlyD family secretion protein -
M9O80_RS22950 (M9O80_22950) 4728393..4728857 - 465 WP_008807598.1 MarR family transcriptional regulator -
M9O80_RS22955 (M9O80_22955) 4729023..4729187 - 165 WP_008807599.1 DUF1127 domain-containing protein -
M9O80_RS22960 (M9O80_22960) 4729365..4730777 + 1413 WP_008807600.1 PLP-dependent aminotransferase family protein -
M9O80_RS22965 (M9O80_22965) 4730857..4731159 - 303 WP_022065028.1 BrnA antitoxin family protein Antitoxin
M9O80_RS22970 (M9O80_22970) 4731146..4731433 - 288 WP_012542979.1 BrnT family toxin Toxin
M9O80_RS22975 (M9O80_22975) 4731601..4732020 - 420 WP_023297004.1 FosA5 family fosfomycin resistance glutathione transferase -
M9O80_RS22980 (M9O80_22980) 4732014..4732922 - 909 WP_016160219.1 LysR family transcriptional regulator -
M9O80_RS22985 (M9O80_22985) 4733009..4733791 + 783 WP_012542981.1 NAD(P)H-dependent oxidoreductase -
M9O80_RS22990 (M9O80_22990) 4733933..4734517 + 585 WP_004182816.1 TetR/AcrR family transcriptional regulator -
M9O80_RS22995 (M9O80_22995) 4734539..4735342 + 804 WP_048267404.1 winged helix-turn-helix domain-containing protein -
M9O80_RS23000 (M9O80_23000) 4735339..4735857 + 519 WP_023297001.1 FidL-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(38-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11245.77 Da        Isoelectric Point: 8.6574

>T246273 WP_012542979.1 NZ_CP097808:c4731433-4731146 [Klebsiella variicola]
MPMEFEWDANKALSNLRKHGVRFEEAVLVFDDPRHLSRQERFENGEYRWQTIGLVHGILVILVAHSVRFESGTEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11320.98 Da        Isoelectric Point: 10.3129

>AT246273 WP_022065028.1 NZ_CP097808:c4731159-4730857 [Klebsiella variicola]
MSMVKHKRGNTAALTAKRDAELKALASKADEDIDYSDIPATDDAQWSDAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMIRDLNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References