Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2722354..2723942 Replicon chromosome
Accession NZ_CP097808
Organism Klebsiella variicola strain 17YN56

Toxin (Protein)


Gene name hipA Uniprot ID A0A0B7G636
Locus tag M9O80_RS13335 Protein ID WP_012968244.1
Coordinates 2722354..2723676 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1F2MCN9
Locus tag M9O80_RS13340 Protein ID WP_008804920.1
Coordinates 2723676..2723942 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O80_RS13320 (M9O80_13320) 2717420..2719921 + 2502 WP_049153029.1 fimbria/pilus outer membrane usher protein -
M9O80_RS13325 (M9O80_13325) 2719909..2720913 + 1005 WP_088717112.1 fimbrial protein -
M9O80_RS13330 (M9O80_13330) 2721045..2722337 + 1293 WP_012968243.1 glycoside hydrolase family 10 protein -
M9O80_RS13335 (M9O80_13335) 2722354..2723676 - 1323 WP_012968244.1 type II toxin-antitoxin system HipA family toxin Toxin
M9O80_RS13340 (M9O80_13340) 2723676..2723942 - 267 WP_008804920.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M9O80_RS13345 (M9O80_13345) 2724208..2724543 - 336 WP_088717111.1 hydroxyisourate hydrolase -
M9O80_RS13350 (M9O80_13350) 2724540..2725040 - 501 WP_064170224.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M9O80_RS13355 (M9O80_13355) 2725018..2726397 - 1380 WP_012968246.1 nucleobase:cation symporter-2 family protein -
M9O80_RS13360 (M9O80_13360) 2726743..2727897 + 1155 WP_117115537.1 FAD-dependent urate hydroxylase HpxO -
M9O80_RS13365 (M9O80_13365) 2727878..2728801 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48896.29 Da        Isoelectric Point: 7.9109

>T246270 WP_012968244.1 NZ_CP097808:c2723676-2722354 [Klebsiella variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGELMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.30 Da        Isoelectric Point: 8.5912

>AT246270 WP_008804920.1 NZ_CP097808:c2723942-2723676 [Klebsiella variicola]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7G636

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MCN9

References