Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1587793..1588790 Replicon chromosome
Accession NZ_CP097808
Organism Klebsiella variicola strain 17YN56

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag M9O80_RS07705 Protein ID WP_228961040.1
Coordinates 1588236..1588790 (-) Length 185 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M9O80_RS07700 Protein ID WP_250294563.1
Coordinates 1587793..1588239 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O80_RS07685 (M9O80_07685) 1584088..1585086 + 999 WP_008804028.1 galactose/glucose ABC transporter substrate-binding protein MglB -
M9O80_RS07690 (M9O80_07690) 1585205..1586725 + 1521 WP_008804029.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
M9O80_RS07695 (M9O80_07695) 1586741..1587751 + 1011 WP_002912871.1 galactose/methyl galactoside ABC transporter permease MglC -
M9O80_RS07700 (M9O80_07700) 1587793..1588239 - 447 WP_250294563.1 helix-turn-helix transcriptional regulator Antitoxin
M9O80_RS07705 (M9O80_07705) 1588236..1588790 - 555 WP_228961040.1 HipA domain-containing protein Toxin
M9O80_RS07710 (M9O80_07710) 1588819..1589340 - 522 WP_025714688.1 hypothetical protein -
M9O80_RS07715 (M9O80_07715) 1589455..1590186 - 732 WP_008804033.1 outer membrane permeability protein SanA -
M9O80_RS07720 (M9O80_07720) 1590463..1591347 - 885 WP_012967554.1 cytidine deaminase -
M9O80_RS07725 (M9O80_07725) 1591476..1592171 - 696 WP_008804035.1 CidB/LrgB family autolysis modulator -
M9O80_RS07730 (M9O80_07730) 1592161..1592565 - 405 WP_004201620.1 CidA/LrgA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(2-147)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 185 a.a.        Molecular weight: 20639.90 Da        Isoelectric Point: 5.7891

>T246264 WP_228961040.1 NZ_CP097808:c1588790-1588236 [Klebsiella variicola]
MRLGMESVYSLLQKAPATILDHETTLRILIEKITSSNMVRVQNYRFDVQGFIIDWVRRDLLNIIFGNSDNHGRNTAFMKA
DNEITLAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWIAPDTLLNALSETASQLVDLPSRLKARGVP
VQILEMPSIGFKFIPDKLARWGLL

Download         Length: 555 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16422.13 Da        Isoelectric Point: 10.5417

>AT246264 WP_250294563.1 NZ_CP097808:c1588239-1587793 [Klebsiella variicola]
MKTLNKKETEIQNTLARLRADNPPSLPATGVTATEKKARLEISRQRVSAGLKKVKTVDRQAVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIYKPFGLETGLVPISKTLISSLFK

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References