Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 793832..794489 Replicon chromosome
Accession NZ_CP097808
Organism Klebsiella variicola strain 17YN56

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag M9O80_RS03920 Protein ID WP_002916310.1
Coordinates 794079..794489 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M9O80_RS03915 Protein ID WP_002916312.1
Coordinates 793832..794098 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O80_RS03895 (M9O80_03895) 790275..791003 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
M9O80_RS03900 (M9O80_03900) 791054..791365 + 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
M9O80_RS03905 (M9O80_03905) 791528..792187 + 660 WP_008806429.1 hemolysin III family protein -
M9O80_RS03910 (M9O80_03910) 792603..793586 - 984 WP_171356132.1 tRNA-modifying protein YgfZ -
M9O80_RS03915 (M9O80_03915) 793832..794098 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M9O80_RS03920 (M9O80_03920) 794079..794489 + 411 WP_002916310.1 protein YgfX Toxin
M9O80_RS03925 (M9O80_03925) 794496..795017 - 522 WP_008806427.1 flavodoxin FldB -
M9O80_RS03930 (M9O80_03930) 795118..796014 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
M9O80_RS03935 (M9O80_03935) 796037..796750 + 714 WP_008806425.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M9O80_RS03940 (M9O80_03940) 796756..798489 + 1734 WP_117115731.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T246263 WP_002916310.1 NZ_CP097808:794079-794489 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT246263 WP_002916312.1 NZ_CP097808:793832-794098 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References