Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 1693519..1694120 Replicon chromosome
Accession NZ_CP097807
Organism Thalassospira sp. GO-4

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag M9H61_RS08010 Protein ID WP_250284383.1
Coordinates 1693519..1693773 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M9H61_RS08015 Protein ID WP_250284386.1
Coordinates 1693770..1694120 (+) Length 117 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9H61_RS07975 (M9H61_07975) 1688529..1689197 - 669 WP_250284370.1 phage tail protein -
M9H61_RS07980 (M9H61_07980) 1689287..1689562 - 276 WP_250284371.1 hypothetical protein -
M9H61_RS07985 (M9H61_07985) 1689624..1690439 - 816 WP_250284373.1 phage capsid protein -
M9H61_RS07990 (M9H61_07990) 1690578..1691279 - 702 WP_250284375.1 hypothetical protein -
M9H61_RS07995 (M9H61_07995) 1691272..1691535 - 264 WP_250284378.1 hypothetical protein -
M9H61_RS08000 (M9H61_08000) 1691532..1693127 - 1596 WP_250284380.1 portal protein -
M9H61_RS08005 (M9H61_08005) 1693172..1693411 - 240 WP_250284382.1 hypothetical protein -
M9H61_RS08010 (M9H61_08010) 1693519..1693773 + 255 WP_250284383.1 type II toxin-antitoxin system HicA family toxin Toxin
M9H61_RS08015 (M9H61_08015) 1693770..1694120 + 351 WP_250284386.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M9H61_RS08020 (M9H61_08020) 1694364..1694900 - 537 WP_250284388.1 hypothetical protein -
M9H61_RS08025 (M9H61_08025) 1694888..1695328 - 441 WP_250284390.1 hypothetical protein -
M9H61_RS08030 (M9H61_08030) 1695953..1696267 + 315 WP_250284393.1 hypothetical protein -
M9H61_RS08035 (M9H61_08035) 1696304..1697338 - 1035 WP_068517990.1 LacI family DNA-binding transcriptional regulator -
M9H61_RS08040 (M9H61_08040) 1697488..1698498 + 1011 WP_250284395.1 TRAP transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1674429..1696267 21838


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-72)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9514.19 Da        Isoelectric Point: 10.5677

>T246260 WP_250284383.1 NZ_CP097807:1693519-1693773 [Thalassospira sp. GO-4]
MGRQDKLIARLKGKPKDFSWDELVRLLTSLGYREVKTGKSGGSRRKFVHGTAPTIALHKPHPGNIVKSYVIDYVLELLIE
EKLI

Download         Length: 255 bp

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 13075.66 Da        Isoelectric Point: 4.7699

>AT246260 WP_250284386.1 NZ_CP097807:1693770-1694120 [Thalassospira sp. GO-4]
MSTMLEYNGYLGSVEFSDADEIFHGKLEFIRDLVTYEGTDAKSLKAAFHEAVDDYLELCQDEGRTPDTPLKGSFNIRPGH
DLHRRAILLASRRGVKLNNVVTDALRAYLDREDVVA

Download         Length: 351 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References