Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 253950..255594 Replicon chromosome
Accession NZ_CP097799
Organism Pasteurella multocida strain 39639

Toxin (Protein)


Gene name hipA Uniprot ID V4NI19
Locus tag M9410_RS01215 Protein ID WP_005752891.1
Coordinates 253950..255257 (+) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID V4NAB0
Locus tag M9410_RS01220 Protein ID WP_005752888.1
Coordinates 255259..255594 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9410_RS01205 (M9410_01205) 249947..252529 + 2583 WP_005758039.1 DNA mismatch repair protein MutS -
M9410_RS01210 (M9410_01210) 252595..253713 - 1119 WP_005758041.1 anhydro-N-acetylmuramic acid kinase -
M9410_RS01215 (M9410_01215) 253950..255257 + 1308 WP_005752891.1 HipA domain-containing protein Toxin
M9410_RS01220 (M9410_01220) 255259..255594 + 336 WP_005752888.1 helix-turn-helix transcriptional regulator Antitoxin
M9410_RS01225 (M9410_01225) 255690..256358 - 669 WP_005758044.1 NAD(P)H-dependent oxidoreductase -
M9410_RS01230 (M9410_01230) 256399..257766 - 1368 WP_032851708.1 oxygen-independent coproporphyrinogen III oxidase -
M9410_RS01235 (M9410_01235) 257790..258218 - 429 WP_005724851.1 DUF2489 domain-containing protein -
M9410_RS01240 (M9410_01240) 258224..258793 - 570 WP_005758047.1 Der GTPase-activating protein YihI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-375)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-94)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 50526.31 Da        Isoelectric Point: 4.9118

>T246248 WP_005752891.1 NZ_CP097799:253950-255257 [Pasteurella multocida]
MEKLTLQIYLEQAWCDLAFLYFDSETYQLCNFEYLTDYVVQHYGKTGEHAVSLNYPVNVFIDDTTSLWSWLSDIAPAGAS
RRYWLEALDIKQESEEKQQFLLLKHAAISPIGNLRIKDAVPEQVEVRLFDLDKAKDRQSDFLEYVNQSGAMVGGATGAGG
EAPKLLLKRRENQVWIDNQQQGQDQDVSYLVKYPRGNYSPIDCDILRAEYHYYQELAQLGFDTIDTTRMRLEEGKRYPSL
WLPRFDIVQREGKTHRLAFESVYSLLQKQGGVLDHETTLRQLIERISTARLQFAQTDFVIEWVKRDLLNIAFGNSDNHGR
NMAFLRDEQRIWLAPIYDFAPMRADPEGIIRTTTWQTKGEYPQEFAGEYHFERIAEVLADLVEPTLLMQELRRLAGSLVD
LKSRLVQRNLPQSILDFPAIGFDYLPEKLKKWGLI

Download         Length: 1308 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12520.60 Da        Isoelectric Point: 10.5259

>AT246248 WP_005752888.1 NZ_CP097799:255259-255594 [Pasteurella multocida]
MQITRRNASTKGASVAEIDRKKVRNEIIQAMLMGELSQGEALRKLRIEMFGINQQHYIQLVKVSRQTLSNIENDKGNYSV
ETINKVFKPFGLELGLVPVSKALLKELFSTA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V4NI19

Antitoxin

Source ID Structure
AlphaFold DB V4NAB0

References