Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 699096..699670 Replicon chromosome
Accession NZ_CP097798
Organism Pasteurella multocida strain 29792

Toxin (Protein)


Gene name PumA Uniprot ID A0A849CFF7
Locus tag M9416_RS03475 Protein ID WP_014667974.1
Coordinates 699096..699380 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A849CG04
Locus tag M9416_RS03480 Protein ID WP_014391174.1
Coordinates 699377..699670 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9416_RS03455 (M9416_03455) 694558..696744 + 2187 WP_014667973.1 S8 family peptidase -
M9416_RS03460 (M9416_03460) 697044..697229 + 186 WP_016534551.1 hypothetical protein -
M9416_RS03465 (M9416_03465) 697541..697802 + 262 Protein_663 hypothetical protein -
M9416_RS03475 (M9416_03475) 699096..699380 + 285 WP_014667974.1 addiction module protein Toxin
M9416_RS03480 (M9416_03480) 699377..699670 + 294 WP_014391174.1 putative addiction module antidote protein Antitoxin
M9416_RS03485 (M9416_03485) 700068..700745 - 678 WP_014667975.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
M9416_RS03490 (M9416_03490) 700763..701230 - 468 WP_014391172.1 PTS sugar transporter subunit IIA -
M9416_RS03495 (M9416_03495) 701275..703065 - 1791 WP_014667976.1 PTS ascorbate-specific subunit IIBC -
M9416_RS03500 (M9416_03500) 703414..704505 + 1092 WP_005756839.1 L-ascorbate 6-phosphate lactonase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 697641..697802 161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-85)

Antitoxin

Uncharacterized protein HI1420

(5-92)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10702.41 Da        Isoelectric Point: 10.2849

>T246247 WP_014667974.1 NZ_CP097798:699096-699380 [Pasteurella multocida]
VGRLREVKNLSAKAAVLARINRVMNGNLGDHKSIGNGLYEMRIIKGSGYRVYYGQYREVTYLLICGGDKSTQKSDIVKAR
ELWKEIKQQEEVKV

Download         Length: 285 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.80 Da        Isoelectric Point: 8.9149

>AT246247 WP_014391174.1 NZ_CP097798:699377-699670 [Pasteurella multocida]
MSKKKIKLKLFDIAEHLDSEEMIAAYLSEVLETCDTNEFISALADVVRAKGMTELAAKTGLRRESLYKTLSYGSKPRFDT
IMKITHSLGIKLVPTHI

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A849CFF7

Antitoxin

Source ID Structure
AlphaFold DB A0A849CG04

References