Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 381493..382067 Replicon chromosome
Accession NZ_CP097797
Organism Pasteurella multocida strain 29135

Toxin (Protein)


Gene name PumA Uniprot ID A0A849CFF7
Locus tag M9418_RS01720 Protein ID WP_014667974.1
Coordinates 381783..382067 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A849CG04
Locus tag M9418_RS01715 Protein ID WP_014391174.1
Coordinates 381493..381786 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9418_RS01695 (M9418_01695) 376658..377749 - 1092 WP_005756839.1 L-ascorbate 6-phosphate lactonase -
M9418_RS01700 (M9418_01700) 378098..379888 + 1791 WP_014667976.1 PTS ascorbate-specific subunit IIBC -
M9418_RS01705 (M9418_01705) 379933..380400 + 468 WP_014391172.1 PTS sugar transporter subunit IIA -
M9418_RS01710 (M9418_01710) 380418..381095 + 678 WP_014667975.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
M9418_RS01715 (M9418_01715) 381493..381786 - 294 WP_014391174.1 putative addiction module antidote protein Antitoxin
M9418_RS01720 (M9418_01720) 381783..382067 - 285 WP_014667974.1 addiction module protein Toxin
M9418_RS01730 (M9418_01730) 383361..383622 - 262 Protein_334 hypothetical protein -
M9418_RS01735 (M9418_01735) 383934..384119 - 186 WP_016534551.1 hypothetical protein -
M9418_RS01740 (M9418_01740) 384419..386605 - 2187 WP_014667973.1 S8 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 383361..383522 161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-85)

Antitoxin

Uncharacterized protein HI1420

(5-92)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10702.41 Da        Isoelectric Point: 10.2849

>T246245 WP_014667974.1 NZ_CP097797:c382067-381783 [Pasteurella multocida]
VGRLREVKNLSAKAAVLARINRVMNGNLGDHKSIGNGLYEMRIIKGSGYRVYYGQYREVTYLLICGGDKSTQKSDIVKAR
ELWKEIKQQEEVKV

Download         Length: 285 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.80 Da        Isoelectric Point: 8.9149

>AT246245 WP_014391174.1 NZ_CP097797:c381786-381493 [Pasteurella multocida]
MSKKKIKLKLFDIAEHLDSEEMIAAYLSEVLETCDTNEFISALADVVRAKGMTELAAKTGLRRESLYKTLSYGSKPRFDT
IMKITHSLGIKLVPTHI

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A849CFF7

Antitoxin

Source ID Structure
AlphaFold DB A0A849CG04

References